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Pharmacist Leonie Verheyen (née Wallmeyer)

Leonie Wallmeyer

Institute of Pharmaceutical Sciences

Pharmacology

Freie Universität Berlin

PhD Candidate

Field of Activity

Development and Characterization of an In Vitro Skin Model of Atopic Dermatitis

Address Königin-Luise-Str. 2+4
14195 Berlin
Email leonie.verheyen@fu-berlin.de

Development and Characterization of an In Vitro Skin Model of Atopic Dermatitis

Atopic dermatitis is a chronic, inflammatory skin disease, and is one of the most common skin disorders in children in industrial countries. Loss-of-function mutations in the filaggrin gene are the most-widely occurring genetic risk factors for atopic dermatitis known to date. Various atopic animal models are described in the literature, but problems such as limited availability and data reproducibility, interspecies-related problems and ethical issues still remain. Motivated by these problems, the overall aim is to establish a skin model mimicking hallmarks of atopic skin in vitro which allows to study pathophysiological aspects as well as new drug candidates or therapeutic options.

 

-> funded by Stiftung SET

TSLP is a direct trigger for T cell migration in filaggrin-deficient skin equivalents

Wallmeyer, L., Dietert, K., Sochorova, M., Gruber, A. D., Kleuser, B., Vavrova, K. and Hedtrich, S.
Sci Rep | 2017

pH-Modulating Poly(ethylene glycol)/Alginate Hydrogel Dressings for the Treatment of Chronic Wounds

Koehler, J., Wallmeyer, L., Hedtrich, S., Goepferich, A. M., Brandl, F. P.
Macromol Biosci | 2016

Influence of Th2 Cytokines on the Cornified Envelope, Tight Junction Proteins, and ss-Defensins in Filaggrin-Deficient Skin Equivalents

Honzke, S., Wallmeyer, L., Ostrowski, A., Radbruch, M., Mundhenk, L., Schafer-Korting, M., Hedtrich, S.
J Invest Dermatol | 2016

The effect of endothelialization on the epidermal differentiation in human three-dimensional skin constructs - A morphological study

Khiao In, M., L. Wallmeyer, S. Hedtrich, K. C. Richardson, J. Plendl and S. Kaessmeyer
Clin Hemorheol Microcirc | 2015

Stimulation of PPARalpha normalizes the skin lipid ratio and improves the skin barrier of normal and filaggrin deficient reconstructed skin

Wallmeyer, L., D. Lehnen, N. Eger, M. Sochorova, L. Opalka, A. Kovacik, K. Vavrova and S. Hedtrich
J Dermatol Sci | 2015