The FEI Talos™ Arctica TEM is especially suited for high-resolution 3D cryo-imaging, namely for cryo-tomography or imaging of synthetic supramolecular assemblies or biological macromolecular complexes. The 200kV FEG machine is equipped with an automated loading device (“autoloader”) for up to 12 samples combined with an integrated liquid nitrogen Autofill system for long-term cryo-sample stability. A “Volta phase plate” enables close-to-focus image data acquisition with substantially enhanced image contrast. The “Falcon III” direct electron detector allows high resolution imaging at very low electron exposure at frame rates of up to 25ms/frame (“movie mode”). EPU software enables automated data acquisition.