Investigation to quantify multivalent interactions using Quartz Crystal Microbalance

mutiple ligands
one multivalent ligand
bond to a functionalized surface

In the framework of the CRC 765 “Multivalenz als chemisches Organisations- und Wirkprinzip: Neue Architekturen, Funktionen und Anwendungen” the group is enganged in collaborative projects to quantify multivalent interactions using a quartz crystal microbalance with dissipation monitoring (QCM-D). In collaboration with the group of Christina Graf the interaction of functionalized silica particles with gold surfaces is studied with the focus to determine the impact of surface morphology on multivalent interactions. The investigations aim at a control of such interactions on the nanometer level.

In collaboration with the group of Jens Dernedde surfaces functionalized with proper ligands are used to quantify the multivalent interactions of selectins enabled by a proper display of the ligands as well as the selectins. Within these projects the QCM-D method will be compared to other techniques used within the CRC to quantify multivalent interactions, in particular surface plasmon resonance.

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