Within the so called intrinsic pathway of blood coagulation, clotting is initiated by contact with surfaces and materials that are foreign to the body. In order to prevent blood clotting and subsequent thrombus formation, blood contacting surfaces for biomedical applications are modified. A typical approach involves a surface coating with heparin which is a naturally occurring polysulfate with strong anticoagulant properties. Alternatively, neutral, protein-resistant polymers are also effective in suppressing thrombus formation. We are currently investigating antithrombotic surfaces made of anticoagulants with defined anchor functionalities for a universal, substrate-independent and covalent surface immobilization and modification. This project is a part of a collaboration with Dr. Rainer Haag at Freie Universität Berlin, Dr. Jens Dernedde at Charité Berlin and Dr. Jay Kizhakkedathu at the Center for Blood Research at the University of British Columbia, Vancouver, Canada. Funding is currently provided through the Focus Area NanoScale of the Freie Universität Berlin.
We are grateful to the Focus Area NanoScale of FUB for financial support.