Effect of Polymer Brush Architecture on Antibiofouling Properties

Gesine Gunkel, Marie Weinhart, Tobias Becherer, Rainer Haag, Wilhelm T. S. Huck— 2011

Polymer brushes show great promise in next-generation antibiofouling surfaces. Here, we have studied the influence of polymer brush architecture on protein resistance. By carefully optimizing reaction conditions, we were able to polymerize oligoglycerol-based brushes with sterically demanding linear or dendronized side chains on gold surfaces. Protein adsorption from serum and plasma was analyzed by surface plasmon resonance. Our findings reveal a pronounced dependence of biofouling on brush architecture. Bulky yet flexible side chains as in dendronized brushes provide an ideal environment to repel protein—possibly through formation of a hydration layer, which can be further enhanced by presenting free hydroxyl groups on the polymer brushes. A deeper understanding of how brush architecture influences protein resistance will ultimately enable fabrication of surface coatings tailored to specific requirements in biomedical applications.

TitleEffect of Polymer Brush Architecture on Antibiofouling Properties
AuthorGesine Gunkel, Marie Weinhart, Tobias Becherer, Rainer Haag, Wilhelm T. S. Huck
PublisherACS
Date20110920
IdentifierDOI: 10.1021/bm200943m
Source(s)
CitationBiomacromolecules, 2011, 12 (11), 4169–4172.
Languageeng
TypeText