Assessing cooperativity in supramolecular systems

L.K.S. von Krbek, C.A. Schalley, P. Thordarson— 2017

This tutorial review summarises different aspects of cooperativity in supramolecular complexes. We propose a systematic categorisation of cooperativity into cooperative aggregation, intermolecular (allosteric) cooperativity, intramolecular (chelate) cooperativity and interannular cooperativity and discuss approaches to quantify them thermodynamically using cooperativity factors. A brief summary of methods to determine the necessary thermodynamic data is given with emphasis on isothermal titration calorimetry (ITC), a method still underrepresented in supramolecular chemistry, which however offers some advantages over others. Finally, a discussion of very few selected examples, which highlight different aspects to illustrate why such an analysis is useful, rounds up this review.

Assessing cooperativity in supramolecular systems
AuthorL.K.S. von Krbek, C.A. Schalley, P. Thordarson
IdentifierDOI: 10.1039/C7CS00063D
CitationChem. Soc. Rev. 2017, 46, 2622-2637