Takudrei

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Thermodynamic Analysis of Allosteric and Chelate Cooperativity in Di- and Trivalent Ammonium/Crown-Ether Pseudorotaxanes

K. Nowosinski, L.K.S. von Krbek, N.L. Traulsen, C.A. Schalley— 2015

A detailed thermodynamic analysis of the axle-wheel binding in di- and trivalent secondary ammonium/[24]crown-8 pseudorotaxanes is presented. Isothermal titration calorimetry (ITC) data and double mutant cycle analyses reveal an interesting interplay of positive as well as negative allosteric and positive chelate cooperativity thus providing profound insight into the effects governing multivalent binding in these pseudorotaxanes.

Title215
Thermodynamic Analysis of Allosteric and Chelate Cooperativity in Di- and Trivalent Ammonium/Crown-Ether Pseudorotaxanes
AuthorK. Nowosinski, L.K.S. von Krbek, N.L. Traulsen, C.A. Schalley
Date20151006
IdentifierDOI: 10.1021/acs.orglett.5b02592
Source(s)
CitationOrg. Lett. 2015, 17, 5076-5079
TypeText