Takudrei

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Enzyme-responsive polymer-substituted pillar[5]arene amphiphiles: synthesis, self-assembly in water, and application in controlled drug release

L. Gao, B. Zheng, W. Chen, C.A. Schalley— 2015

An enzyme-responsive drug delivery system was constructed from a pillar[5]arene-based polyethyleneglycol-substituted amphiphile which self-assembles into micelles in water. These micelles exhibit superior drug encapsulation capability, and display drug release behaviour in response to enzyme catalysis, in partiular to L-asparaginase. Doxorubicin-loaded micelles show significant cytotoxicity against MCF-7 cancer cells.

Title213
Enzyme-responsive polymer-substituted pillar[5]arene amphiphiles: synthesis, self-assembly in water, and application in controlled drug release
AuthorL. Gao, B. Zheng, W. Chen, C.A. Schalley
Date20150814
IdentifierDOI: 10.1039/C5CC06207A
Source(s)
CitationChem. Commun. 2015, 51, 14901-14904
TypeText