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Salicylate-Functionalized Bismuth Oxido Clusters: Hydrolysis Processes and Microbiological Activity

M. Schlesinger, A. Pathak, S. Richter, D. Sattler, A, Seifert, T. Rüffer, P. C. Andrews, C. A. Schalley, H. Lang, M. Mehring— 2014

Hydrolysis of either Bi(HSal4Me)3 (A) or [Bi22O26(HSal4Me)14] (B) in DMSO gave the 4-methylsalicylate-substituted bismuth oxido cluster [Bi38O45(HSal4Me)24(DMSO)14(H2O)2]∙4H2O (1∙4H2O) which crystallizes in the triclinic space group P1¯ with cell parameters of a = 20.7214(5) Å, b = 20.9654(6) Å, c = 22.2128(6) Å, α = 100.867(2)°, β = 114.108(2)°, γ = 107.895(2)° and V = 7815.1(4) ų. Studies on the hydrolysis of A were performed using 1H DOSY NMR spectroscopy and electrospray ionisation Fourier-transform ion-cyclotron-resonance (ESI-FTICR) mass spectrometry which both show the formation of several larger species under ambient conditions in the presence of moisture. Furthermore, ESI- FTICR MS of cluster B shows the formation of mainly {Bi23O26} species which indicates partial dissociation of cluster B in solution. Additionally, the three different bismuth species containing one (A), 22 (B) or 38 (1∙4H2O) bismuth atoms per molecular formula were tested for their microbiological activity against three strains of Helicobacter pylori (251, 26695 and B128). A minimum inhibitory concentration (MIC) value of 6.25 µg/mL for the mononuclear bismuth complex A was obtained whereas the bismuth oxido cluster B shows a lower activity with MIC values between 25 μg/mL and 50.0 μg/mL. The activity of 1∙4H2O is comparable to commercial remedies based on antimicrobial bismuth subsalicylate (BSS; 12.5 ug/mol).

Title201
Salicylate-Functionalized Bismuth Oxido Clusters: Hydrolysis Processes and Microbiological Activity
AuthorM. Schlesinger, A. Pathak, S. Richter, D. Sattler, A, Seifert, T. Rüffer, P. C. Andrews, C. A. Schalley, H. Lang, M. Mehring
Date20140718
IdentifierDOI 10.1002/ejic.201402493
Source(s)
CitationEur. J. Inorg. Chem., 2014, 4218-4227
TypeText