Is there a Beta-Peptide Equivalent of the Alpha-Helix?

Baldauf, C.*; Schubert, F.; Pagel, K.; Warnke, S.; Rossi, M.; Salwiczek, M.; Koksch, B.; von Helden, G.; Blum, V.— 2014

In organic chemistry, the concept of homologation describes the extension of a carbon chain by one methylene unit. The application of this concept to peptides gives rise to the class of β-peptides that feature an additional -CH2- unit in the monomer backbone. The study of such non-natural peptides offers insight into general folding mechanisms. The similarities to α-peptide structure combined with stability against proteases makes such foldamers promising scaffolds with possible applications in drug design.

TitleIs there a Beta-Peptide Equivalent of the Alpha-Helix?
AuthorBaldauf, C.*; Schubert, F.; Pagel, K.; Warnke, S.; Rossi, M.; Salwiczek, M.; Koksch, B.; von Helden, G.; Blum, V.
Date2014
Identifier10.1016/j.bpj.2013.11.3621
Source(s)
CitationBiophys. J. 2014, 106, 654a.
TypeText