From α-helix to β-sheet - A reversible metal ion induced peptide secondary structure switch

Pagel, K.; Vagt, T.; Kohajda, T.; Koksch, B.— 2005

Here we introduce a peptide model based on an α-helical coiled coil peptide, providing a simple system which can be used for a systematic study of the impact of different metal ions in different oxidation states on peptide secondary structure on a molecular level; histidine residues were incorporated into the heptad repeat to generate possible complexation sites for Cu2+ and Zn2+ ions.

TitleFrom α-helix to β-sheet - A reversible metal ion induced peptide secondary structure switch
AuthorPagel, K.; Vagt, T.; Kohajda, T.; Koksch, B.
Date2005
Identifier10.1039/B505979H
Source(s)
CitationOrg. Biomol. Chem. 2005, 3, 2500-2502
TypeText

Highlighted in: Switching off neurodegenerative diseases, Chemistry World 2005, 2(8).