Publication List

123 publications

Xenobiology meets enzymology: Exploring the potential of unnatural building blocks in biocatalysis

F. Agostini, J.-S. Völler, B. Koksch, C.G. Acevedo-Rocha, V. Kubyshkin, N. Budisa

Angew. Chem. Int. Ed., 2017, 10.1002/anie.201610129

Discovery and investigations of editing function of natural AARSs against synthetic perfluorinated amino acids in protein translation

J. Völler, M. Dulic, U. Gerling-Driessen, H. Biava, T. Baumann, N. Budisa, I. Gruic-Sovuli, B. Koksch

ACS Central Science, 2017, DOI: 10.1021/acscentsci.6b00339

Substrate specificity of an actively assembling amyloid catalyst

J.L. Heier, D.J. Mikolajczak, C. Böttcher, B. Koksch

Biopolymers, 2017, DOI: 10.1002/bip.23003

Inhibition of peptide aggregation by means of enzymatic phosphorylation

K. Folmert, M. Bronzel, H.v. Berlepsch, C.H. Ullricht, M.-A. Siegert, B. Koksch

Beilstein J. Org. Chem. 2016, 12, 2462-2470

A sustainable, semi-continuous flow synthesis of hydantoins

S. Vukelic, B. Koksch, P.H. Seeberger, K. Gilmore

Chem. Eur. J. 2016 22 (38), 13451-13454

Membrane binding of peptide models for early stages of amyloid formation: Lipid packing counts more than charge

M. Hoernke, S. Tassler, B. Koksch, G. Brezesinski

Chem.Phys.Lipids 2016, 198, 28-38

Native like helices in a specially designed beta peptide

F. Schubert, K. Pagel, M. Rossi, S. Warnke, M. Salwiczek, B. Koksch, G. von Helden, V. Blum, C. Baldauf, M. Scheffler

Phys.Chem.Chem.Phys. 2015, 17 (11), 7373-7385

Exploiting oligo(amido amine) backbones for the multivalent presentation of coiled coil peptides

U.I.M. Gerling-Driessen, N. Mujkic-Ninnemann, D. Ponader, D. Schöne, L. Hartmann*, B. Koksch*

Biomacromolecules 2015, 16 (8), 2394-2402

Fluorine teams up with water to restore inhibitor activity to mutant BPTI

S. Ye, B. Loll, A.A. Berger, U. Mülow, C. Alings, M. Wahl, B. Koksch

Chem.Sci. 2015, 6, 5246-5254

Synthesis of fluorinated α-amino acids in flow

S. Vukelić, D. B. Ushakov, K. Gilmore, B. Koksch, P. H. Seeberger*

Eur. J. Org. Chem. 2015, 14, 3036-3039

Multivalent electrostatic interactions between coiled coil peptides and gold nanoparticles direct colloid assembly

D. Schöne, S. C. Wagner, B. Koksch

Beilstein J. Org. Chem. 2015, 11, 792-803

Orthogonal translation meets electron transfer: In vito labeling of cytochrome C for probing local electric fields

J. Völler, H. Biava, B. Koksch, P. Hildebrandt, Nediljko Budisa

ChemBioChem 2015, 16 (5) 742-745

Coiled coils in phage display screening: Insight into exceptional selectivity provided by molecular dynamics and umbrella sampling

J. Mortier, E.K. Nyakatura, O. Reimann, S. Huhmann, J. Daldrop, C. Baldauf, G. Wolber, M.S. Miettinen, B. Koksch

J. Chem. Inf. Mod. 2015, 55 (3), 495-500

Coiled coil-based glycopeptides as precision tools for structural characterization of the asialoglycoprotein receptor

E. Zacco, J. Hütter, B. Lepenies, B. Koksch

ACS Chemical Biology 2015, 10, (9), 2065-2072

Concluding the amyloid formation pathway from the size of the critical nucleus

U.I.M. Gerling, M.S. Miettinen, B. Koksch

ChemPhysChem | 2015

16 (1), 108-114

Fluorine meets peptides

Beate Koksch, Ulla Gerling-Driessen

Abstract

β- and γ-Amino Acids at α-Helical Interfaces: Towards the Formation of Highly Stable Foldameric Coiled Coils

E.K. Nyakatura, J. Mortier, V. Radtke, S. Wieczorek, R.R. Araghi, C. Baldauf, G. Wolber, B. Koksch

ACS Med Chem Lett. 2014, 5 (12), 1300-1303

Cationic membrane-active peptides - anticancer and antifungal activity as well as penetration into human skin

N. Do, G. Weindl, M. Salwiczek, B. Koksch, H.-C. Korting, M. Schäfer-Korting

Exp Dermatol. 2014, 32 (5), 326-331

An unusual interstrand H-bond stabilizes the hetero-assembly of helical αβγ-chimeras with natural peptides

R. Araghi, E. Nyakatura, J. Mortier, S. Wieczorek, C. Baldauf, G. Wolber, B. Koksch

ACS Chem. Biol. 2014, 9 (3), 613-616

Conformational investigation of short linear peptides containing cis- and trans-proline-glutamate chimeras at the beta-turn position

J. Maity, U.I.M. Gerling, S. Vukelic, A. Schäfer, B. Koksch

Amino Acids 2014, 46 (1), 177-186

Impact of fluorination of peptides on proteolytic stability: a case study with α-chymotrypsin and pepsin

V. Asante, J. Mortier, G. Wolber, B. Koksch

Amino Acids 2014, 46 (12), 2733-2744

Partial side chain fluorination influencing amyloid formation: a symphony of size, hydrophobicity, and α-helix propensity

U.I.M. Gerling, M. Salwiczek, C.D. Cadicamo, H. Erdbrink, S. Grage, P. Wadhwani, A. Ulrich, M. Behrens, G. Haufe, C. Czekelius, B. Koksch

Chem. Sci. 2014, 5 (2), 819-830

A flexible synthesis of enantiomerically pure (2S,3S)-5,5,5-trifluoroisoleucine and (2R,3S)-5,5,5-trifluoro-allo-isoleucine

H. Erdbrink, E.K. Nyakatura, S. Huhmann, U.I.M. Gerling, D. Lentz, B. Koksch, C. Czekelius

Beilstein J. Org. Chem. 2013, 9, 2009-2014

Nanoscale imaging reveals laterally expanding antimicrobial pores

P. Rakowska, H. Jiang, S. Ray, A. Pyne, B. Lamarre, M. Carr, P. Judge, J. Ravi, U. Gerling, B. Koksch, G. Martyna, B. Hoogenboom, A. Watts, J. Crain, C. Grovenor, M. Ryadnov

PNAS 2013, 110, 8918-8923

Abstract

How Cations Change Peptide Structure

C. Baldauf, Kevin Pagel, S. Warnke, G. von Helden, B. Koksch, V. Blum, M. Scheffler

Chem. Eur. J. 2013, 19, 11224-11234

http://onlinelibrary.wiley.com/doi/10.10 ...

Accommodating fluorinated amino acids in helical peptide environments

E. Nyakatura, O. Reimann, T. Vagt, M. Salwiczek, B. Koksch

RSC Advances 2013, 3 (18), 6319 - 6322

http://pubs.rsc.org/en/content/articlela ...

Impact of fluorination on proteolytic stability of peptides in human blood plasma

V. Asante, J. Mortier, H. Schlüter, B. Koksch

Bioorg. Med. Chem. 2013, 21, 3542–-3546

http://www.sciencedirect.com/science/art ...

Design, synthesis, inhibition studies, and molecular modeling of pepstatin analogues addressing different secreted aspartic proteinases of Candida albicans

C.D. Cadicamo, J. Mortier, G. Wolber, M. Hell, I.E. Heinrich, D. Michel, L. Semlin, U. Berger, H.C. Korting, H.D. Holtje, B. Koksch, C. Borelli

Biochem. Pharmac. 2013, 8 (7), 881-887

Formation of α-Helical Nanofibers by Mixing β-Structured and α-Helical Coiled Coil Peptides

E. Brandenburg, H.v. Berlepsch, J. Leiterer, F. Emmerling, B. Koksch

Biomacromolecules, 2012, 13 (11), 3542–-3551

Conjugate Hydrotrifluoromethylation of α,β-Unsaturated Acyl-Oxazolidinones: Synthesis of Chiral Fluorinated Amino Acids

H. Erdbrink, I. Peuser, U.I.M. Gerling, D. Lentz, B. Koksch,* C. Czekelius

Org. Biomol. Chem. 2012, 10, 8583-8586

An approach for simultaneous synthesis of cis- and trans-3-substituted proline-glutamic acid chimeras

J. Maity, P. Saha, U. Gerling, D. Lentz, B. Koksch

Synthesis, 2012, 19

Multivalenz als Chemisches Organisations- und Wirkprinzip

C. Fasting, C.A. Schalley, M. Weber, O. Seitz, S. Hecht, B. Koksch, J. Dernedde, C. Graf, E.-W. Knapp, R. Haag

Angew. Chem. 2012, 124(42), 10622-10650

Multivalency as a Chemical Organization and Action Principle

C. Fasting, C.A. Schalley, M. Weber, O. Seitz, S. Hecht, B. Koksch, J. Dernedde, C. Graf, E.-W. Knapp, R. Haag

Angew. Chem. Int. Ed. 2012, 51(42), 10472-10498

Investigation of the network of preferred interactions in an artificial coiled-coil association using the peptide array technique

R.R. Araghi, C. Mahrenholz, R. Volkmer, B. Koksch

Beilstein J. Org. Chem. 2012, 8, 640-649

Fluorinated amino acids: Compatibility with native protein structures and effects on protein-protein interactions

M. Salwiczek*, E.K. Nyakatura, U.I.M. Gerling, S. Ye, B. Koksch*

Chem.Soc.Rev. 2012, 41 (6), 2135 - 2171

Spectroscopic in situ detection of amyloid fibrils at acidic pH by the fluorophore NIAD-4

E. Brandenburg, H. von Berlepsch, B. Koksch

Molecular Biosystems 2012, 8, 557-564

Molecular interactions of fluorinated amino acids within the hydrophobic core of a coiled coil peptide.

T. Vagt, M. Salwiczek, B. Koksch

Fluorine in pharmaceutical and medicinal chemistry” (ed. V. Gouverneur and K. Müller) Imperial College Press, Vol. 6, 2012, pp. 33-62

β-sheet Structure Formation at the Air-Water Interface: Triggers, Transitions and Orientations

M. Hörnke, J. Falenski, B. Koksch, G. Brezesinski

Eur. Biophys. J. 2011, 40, 89-89

Structure analysis of an amyloid forming model peptide by a systematic glycine- and proline scan

U.I.M. Gerling, E. Brandenburg, H. v. Berlepsch, K. Pagel, B. Koksch

Biomacromolecules, 2011, 12, 2988-2996

Inhibition of Amyloid Aggregation by Formation of Helical Assemblies

Enrico Brandenburg Hans v. Berlepsch Ulla I.M. Gerling C. Böttcher, B. Koksch

Chem. Eur. J., 2011, 17, 10650-10660

A Systematic Study of Fundamentals in α-Helical Coiled Coil Mimicry by Alternating Sequences of β- and γ-Amino Acids

R.R. Araghi, U. Gerling, C.D. Cadicamo, C. Baldauf, B. Koksch

Amino Acids 2011, 41, 733-742

Design and Characterization of Endosomal-pH-Responsive Coiled Coils for Constructing an Artificial Membrane Fusion System

A. Kashiwada, M. Tsuboi, N. Takamura, E. Brandenburg, K. Matsuda, B. Koksch

Chem. Eur. J. 2011, 17 (22), 6179–6186

The APP C-terminal fragment C100 occurs in monomeric and dimeric stable conformations and binds γ-secretase modulators

A. Botev, L.-M. Münter, R. Wenzel, L. Richter, V. Althoff, J. Ismer, U. Gerling, C. Weise, B. Koksch, P.-W. Hildebrand, R. Bittl, G. Multhaup

Biochemistry, 2011, 50 (5), 828-835

Compatibility of the conformationally rigid CF₃-Bpg side chain with the hydrophobic coiled-coil interface

M. Salwiczek, P. K. Mykhailiuk, S. Afonin, I. V. Komarov, A. S. Ulrich, B. Koksch

Amino Acids, 2010, 39, 1589

How Post-translational modifications influence amyloid formation: A systematic study of phosphorylation and glycosylation in model peptides

J.A. Falenski, M. Broncel, S.C. Wagner, C. Hackenberger, B. Koksch

Chem. Eur. J. 2010, 16(26), 7881-88

Nanoparticle-induced peptide folding and aggregation

Wagner, M. Roskamp, M. Pallerla, R.R. Araghi, S. Schlecht, B. Koksch

Small, 2010, 6(12), 1321-28

Multiple glycosylation of de novo designed α-helical coiled coil peptides

J. Falenski, U. Gerling, B. Koksch

Bioorg. Med. Chem. 2010, 18, 3703-3706

Peptide Adsorption to Cyanine Dye Aggregates Revealed by Cryo-Transmission Electron Microscopy

Hans v. Berlepsch, Enrico Brandenburg, Beate Koksch, Christoph Böttcher

Langmuir 2010, 26, 11452-60

Chemical aminoacylation of tRNAs with fluorinated amino acids for in vitro protein mutagenesis

S. Ye, A. A. Berger, D. Petzold, O. Reimann, B. Matt, B. Koksch

Beilstein J Org Chem. 2010, 6, 40

Towards understanding secondary structure transitions: phosphorylation and metal coordination in model peptides

M. Broncel, S.C. Wagner, C. Hackenberger, B. Koksch

Org. Biomol. Chem., 2010, 8, 2575-2579

Enzymatically triggered amyloid formation: an approach for studying aggregation

M. Broncel, S.C. Wagner, C. Hackenberger, B. Koksch

ChemComm., 2010, 46, 3080-3082

Amide-I and -II vibrations of the cyclic β-sheet model peptide gramicidin S in the gas phase

P. Kupser, K. Pagel, J. Oomens, Nick Polfer, B. Koksch, G. Meijer, G. von Helden

J. Am. Chem. Soc., 2010, 132, 2085-2093

A β/γ motif to mimic a-helical turns in proteins

R.R. Araghi, C. Jäckel, M. Salwiczek, S.C. Wagner, S. Wieczorek, C. Baldauf, B. Koksch

ChemBioChem, 2010, 11, 335-339

Fluorine in Protein Environments: A QM and MD Study

Sergey A. Samsonov, Mario Salwiczek, Gerd Anders, Beate Koksch, M. Teresa Pisabarro

J. Phys. Chem. B, 2009, 113, 16400-16408

Effects of Fluorination on the Folding Kinetics of a Heterodimeric Coiled Coil

M. Salwiczek, B. Koksch

ChemBioChem 2009, 10(18), 2867-2870

Direct one-step ¹⁸F-labeling of peptides via nucleophilic aromatic substitution

J. Becaud, L. Mu, M. Karramkam, P.A. Schubiger, S.M. Ametamey, K. Graham, T. Stellfeld, L. Lehmann, S. Borkowski, D.Berndorff, L. Dinkelborg, A. Srinivasan, R. Smits, B. Koksch

Bioconjugate Chem. 2009, 20(12), 2254-2261

Chemical labeling strategy with (R)-and (S)-trifluoromethylalanine for solid state ¹⁹F-NMR analysis of peptaibols in membranes

D. Maisch, P. Wadhwani, S. Afonin, C. Böttcher, B. Koksch, A.S. Ulrich

J. Am. Chem. Soc. 2009, 131(43), 15596-15597

Highly dynamic motion of crown ethers along oligolysine peptide chains

D.P. Weimann, H.D.F. Winkler, J.A. Falenski, B. Koksch, C.A. Schalley

Nat. Chem., 2009, 1(7), 573-577

Selection of a buried salt bridge by phage display

T. Vagt, C. Jaeckel, S. Samsonov, M.T. Pisabarro, B. Koksch

Bioorg. Med. Chem. Let., 2009, 19, 3924-3927

Gas-phase IR spectra of intact α-helical coiled coil protein complexes

K. Pagel, P. Kupser, F. Bierau, N.C. Polfer, J.D. Steill, J. Oomens, G. Meijer, B. Koksch, G. von Helden

Int. J. Mass Spec., 2009, 283, 161-168

Position dependent effects of fluorinated amino acids on hydrophobic core formation of a heterodimeric coiled coil

M. Salwiczek, S. Samsonov, T. Vagt, C. Baldauf, E. Nyakatura, E. Fleige, J. Numata, H. Cölfen, M. T. Pisabarro, B. Koksch

Chem. Eur. J., 2009, 15 (31,) 7628-7636

Investigation of the synthetic route to pepstatin analogues by SPPS using O-protected and O-unprotected statine as building blocks

C. D. Cadicamo, V. Asante, M. Abu Ammar, C. Borelli, H. C. Korting, B. Koksch

J. Pep. Science., 2009, 15, 272-277

Switchable electrostatic interactions between gold nanoparticles and coiled coil peptides direct colloid assembly

S. C. Wagner, M. Roskamp, C. Böttcher, S. Schlecht, B. Koksch

Org. Biomol. Chem., 2009, 7, 46-51

Artificial Model Systems Designed to Investigate Fluorinated Amino Acids in Native Protein Environments

M. Salwiczek, T. Vagt, B. Koksch

I. Ojima (Ed.) Fluorine in Bioorganic and Medicinal Chemistry, Blackwell Publishers, 2009, 391-409

Following polypeptide folding and assembly with conformational switches

K. Pagel, B. Koksch

Curr. Opin. Chem. Biol., 2008, 12, 730-739

Intramolecular Charge Interactions as a Tool to Control the Coiled-Coil-to-Amyloid Transformation

K. Pagel, S. C. Wagner, R.R. Araghi, H. von Berlepsch, C. Böttcher, B. Koksch

Chem. Eur. J., 2008, 14, 11442-11451

Molecular Interactions of Fluorine in a Native Polypeptide Environment

M. Salwiczek, C. Jaeckel, B. Koksch

A. Tressaud, G. Haufe (Eds.) Fluorine & Health - Molecular Imaging, Biomedical Materials and Pharmaceuticals, Elsevier, 2008, 737-759

Identification of thyronamines as isozyme specific deiodinase substrates

S. Piehl, T. Heberer, G. Balizs, T. S. Scanlan, R. Smits, B. Koksch, J. Köhrle

Endocrinology, 2008, 149, 3037-3045

Synthetic Strategies to α-Trifluoro-methyl and α-difluoromethyl substituted α-Amino Acids

R. Smits, C. D. Cadicamo, K. Burger, B. Koksch

Chem. Soc. Rev., 2008, 37, 1455-1464

How metal ions affect amyloid formation - Cu²⁺ and Zn²⁺ sensitive peptides

K. Pagel, T. Seri, H. von Berlepsch, J. Griebel, R. Kirmse, C. Böttcher, B. Koksch

ChemBioChem, 2008, 4, 531-536

A simple machine assisted protocol for solid-phase synthesis of depsipeptides

J. Spengler, B. Koksch, F. Albericio

Biopol. Pept. Sci., 2007, 88, 823-826

Estersubstitutionen in α-helicalen Coiled-Coil-Peptiden: Effekt der Eliminierung von Wasserstoffbrücken auf die Struktur von Proteinen

J. Scheike, C. Baldauf, J. Spengler, R. Albericio, M. T. Pisabarro, B. Koksch

Angew. Chem., 2007, 119, 7912-7916

Amide to ester substitution in coiled coils - The effect of H-bond elimination on protein structure formation

J. Scheike, C. Baldauf, J. Spengler, R. Albericio, M. T. Pisabarro, B. Koksch

Angew. Chem. Int. Ed., 2007, 46, 7766-7769

Membrane binding and structure of de novo designed α-helical cationic coiled coil Peptides

T. Vagt, O. Zschörnig, D. Huster, B. Koksch

ChemPhysChem, 2006, 6, 1361-1371

Random coils, β-sheet ribbons and α-helical fibers - One peptide adopting three different secondary structures at will

K. Pagel, S. C. Wagner, K. Samedov, H. v. Berlepsch, C. Böttcher, B. Koksch

J. Am. Chem. Soc., 2006, 128, 2196-2197

The Formation, Stability and Oligomerization State of two Designed Coiled Coils: A Molecular Dynamics Study

A. Piñeiro, A. Villa, T. Vagt, B. Koksch, Alan E. Mark

Biophys. J., 2005, 89, 1-13

Fluorine in peptide design and protein engineering

C. Jäckel and B. Koksch

Eur. J. Org. Chem., 2005, 21, 4482-4503

Directing polypeptides secondary structure at will - From α-helix to amyloids and reverse?

K. Pagel, T. Vagt, B. Koksch

Org. Biomol. Chem., 2005, 3, 3843-3850

Development of zinc finger domains for recognition of the 5'-CNN-3' family DNA sequences and their use in the construction of artificial transcription factors

B. Dreier, R.P. Fuller, D.J. Segal, C. Lund, P. Blancafort, A. Huber, B. Koksch, C.F. Barbas, III

J. Biol. Chem., 2005, 280, 35588-35597

From α-helix to β-sheet - a reversible metal ion induced peptide secondary structure switch

K. Pagel, T. Kohajda, B. Koksch

Org. Biomol. Chem., 2005, 3, 2500-2502

Advanced approaches for the characterization of a de dovo designed antiparallel coiled coil peptide

K. Pagel, B. Seiwert, K. Seeger, S. Berger, A. Mark, B. Koksch

Org. Biomol. Chem., 2005, 3, 1189-1194

Using the potential of fluorine for peptide and protein modification

C. Jäckel and B. Koksch

V. Soloshonok (Ed.) Fluorine containing synthons ACS Symposium Series 911. American Chemical Society, Washington, DC, 2005, 611-635

Hexafluoroacetone as a protecting and activating reagent: A new approach to O-glycosides

K. Burger, M. Kluge, S. Fehn, B. Koksch, C. Böttcher, L. Hennig, G. Müller

Heterocycles, 2004, 64, 143-152

Hexafluoroacetone as a protecting and activating reagent: Synthesis of fluoro-substituted α-amino, α-hydroxy and α-mercapto acids

S. Osipov, T. Lange, P. Tsouker, J. Spengler, L. Hennig, B. Koksch, S. Berger, S.M. El-Kousy, K. Burger

Synthesis, 2004, 1821-1829

Evaluation of the molecular interactions of fluorinated amino acids with native polypeptides

C. Jäckel, W. Seufert, S. Thust, B. Koksch

ChemBioChem, 2004, 5, 717-720

Enzymatic resolution of Ca-fluoroalkyl amino acids

B. Koksch, T. Michel, P. Kaptain, P. Quaedflieg, Q.B. Broxterman

Tetrahedron: Asymmetry, 2004, 15, 1401-1407

Fluoro-modified chemotactic peptides: fMLF analogues

B. Koksch, Ch. Dahl, G. Radics, A. Vocks, K. Arnold, J. Arnhold, J. Sieler, K. Burger

J. Pept. Sci. 2004, 10, 67-81

L-α-Methylhomoisoserine, a new versatile building block for peptide and depsipeptide modification

G. Radics, B. Koksch, S. M. El-Kousy, J. Spengler, K. Burger

Synlett, 2003, 1826-1829

New building blocks for peptide and depsipeptide synthesis: hexafluoroacetone protected L-homoisoserine and D,L-homoisocysteine derivatives

G. Radics, R. Pires, B. Koksch, S.M. El-Kousy, K. Burger

Tetrahedron Letters, 2003, 44, 1059-1062

Evaluation of a Modular Strategy for the Construction of Novel Polydactyl Zinc Finger DNA-Binding Proteins

D. Segal, R. Beerli, P. Blancafort, B. Dreier, K. Effertz, A. Huber, B. Koksch, C. V. Lund, L. Magnenat, D. Valente, C. F. Barbas, III

Biochemistry, 2003, 42, 2137-2148

Peptide synthesis with α-(difluoromethyl)-substituted α-amino acids

T. Michel, B. Koksch, S. N. Osipov, A. S. Golubev, J. Sieler, K. Burger

Coll. Czech. Chem. Commun,. 2002, 67, 1533-1559

α-Fluoromethyl tryptophanes via imino ene reaction

S. Osipov, N. M. Kobel´kova, A. F. Kolomiets, K. Pumpor, B. Koksch, K. Burger

Synlett, 2001, 1287-1289

First Synthesis of orthogonal protected α-Tfm- and α-Dfm-Arginines

M. Moroni, B. Koksch, S. N. Osipov, M. Crucianelli, M. Frigerio, P. Bravo, K. Burger

J. Org. Chem., 2001, 66, 130-133

Protease catalyzed synthesis of α-fluoroalkyl substituted peptides

S. Thust, B. Koksch, K. Burger

J. Martinez, J.-A. Fehrentz (Eds.) Peptides 2000: Proceedings of the Twenty-Sixth European Peptide Symposium, Editions EDK, Paris, 2001, 347-348

Synthesis of highly fluorinated dipeptide building blocks

B. Koksch, K. Mütze, S. N. Osipov, A. S. Golubev, K. Burger

Tetrahedron Lett., 2000, 41, 3825-3828

Ein neuer Zugang zu Glycopeptiden

K. Burger, M. Kluge, S. Fehn, B. Koksch, L. Hennig, G. Mueller

Angew. Chem. 1999, 111, 1513-1515

A New Approach to Glycopeptides

K. Burger, M. Kluge, S. Fehn, B. Koksch, L. Hennig, G. Mueller

Angew. Chem. Int. Ed. Engl., 1999, 38, 1414-1416

Synthesis of α-fluoroalkyl substituted peptides via enzymatic fragment condensation

F. Bordusa, Ch. Dahl, H.-D. Jakubke, K. Burger, B. Koksch

Tetrahedron: Asymmetry, 1999, 10, 307-313

Influence of α-Fluoroalkyl Substituted Amino Acids on Secondary Structure of Peptides

B. Koksch, H.-D. Jakubke, H. Wenschuh, K. Dietmeier, A. Starostin, A. Woolley, M. Dathe, G. Müller, M. Gußmann, H.-J. Hofmann, Th. Michel, K. Burger

S. Bajusz and F. Hudecz (Eds.) Peptides 1998: Proceedings of the Twenty-Fifths European Peptide Symposium, Académiai Kiadó, Budapest, 1999, 670-671

Influence of α-fluoroalkyl substituted amino acids on secondary structure and properties of peptides

B. Koksch, H.-D. Jakubke, H.-J. Hofmann, M. Gußmann, and K. Burger

Amino Acids, 1997, 13, 73

Proteolytically stable peptides by incorporation of α-Tfm amino acids

B. Koksch, N. Sewald, H.-J. Hofmann, K. Burger, H.-D. Jakubke

J. Peptide Sci., 1997, 3, 157-167

Peptide modification by incorporation of α-trifluoromethyl substituted amino acids

B. Koksch, N. Sewald, K. Burger, H.-D. Jakubke

Amino Acids, 1996, 11, 425-434

Synthesis, Structure and Biological Activity of α-Trifluoromethyl Substituted Thyreotropin Releasing Hormone

B. Koksch, D. Ullmann, H.-D. Jakubke, K. Burger

J. Fluorine Chem., 1996, 80, 53-57

Synthesis and incorporation of α-trifluoromethyl-substituted amino acids into peptides

B. Koksch, N. Sewald, H.-D. Jakubke and K. Burger

I. Ojima, J. R. McCarthy, J. T. Welch (Eds.) Biomedical frontiers of fluorine chemistry ACS Symposium Series 639. American Chemical Society, Washington, DC, 1996, 42-58

Peptide modification by introduction of α-trifluoromethyl substituted amino acids

N. Sewald, W. Hollweck, K. Mütze, C. Schierlinger, L. C. Seymour, K. Gaa, K. Burger, B. Koksch, H.-D. Jakubke

Amino Acids, 1995, 8, 187-194

Synthesis of trifluoromethyl substituted amino acids and their incorporation into peptides

N. Sewald, W. Hollweck, K. Mütze, L. C. Seymour, S. N. Osipov, C. Schierlinger, K. Burger, B. Koksch, H.-D. Jakubke

Peptides 1994: Proceedings of the Twenty-Third European Peptide Symposium (Hrsg. H. L. S. Maia) Leiden, ESCOM Science Publishers, 1994, 327-328

Structure and biological activity of α-trifluoromethyl substituted GnRH and TRH analogues

B. Koksch, D. Ullmann, H.-D. Jakubke, N. Sewald, K. Burger

Peptides 1994: Proceedings of the Twenty-Third European Peptide Symposium (Hrsg. H. L. S. Maia) Leiden, ESCOM Science Publishers, 1994, 323-324

N- und C-terminaler Einbau von α-Trifluormethyl-substituierten Aminosäuren in Azapeptide

K. Burger, C. Schierlinger, K. Mütze, W. Hollweck, B. Koksch

Liebigs Ann. Chem., 1994, 407-413

Untersuchungen zur proteasekatalysierten und chemischen Peptidbindungsknüpfung mit α-trifluormethylsubstituierten α-Aminosäuren

K. Burger, K. Mütze, W. Hollweck, B. Koksch, P. Kuhl, H.-D. Jakubke, J. Riede, A. Schier

J. prakt. Chem., 1993, 335, 321-331