Total synthesis has changed our world profoundly by widely advancing the fields of chemistry, biology and medicine. To ensure future progress, we must explore and exploit reactivity beyond classical patterns. By finding ways to manipulate the aliphatic carbon backbone of molecules, syntheses will become possible that can provide supplies of bioactive natural products and designed analogs expediently, efficiently and economically.
Our aim is to develop robust routes to biologically relevant natural products by harnessing, but not exclusively relying on, C–H-functionalization chemistry. These routes will then be used to access designed analogs of natural products with improved biological and pharmaceutical properties, biological tools and drug candidates which e.g. modulate signal transduction pathways or combat clinically relevant pathogens.
Our target-oriented method development program focusses on novel synthetic methods for C–H-functionalization and their use in the synthesis of biologically relevant molecules. Development of new reagents and reactions, along with a mechanistic understanding of their underpinnings, will be the basis for these endeavors.