8. Exo-Cyclopamine–a stable and potent inhibitor of hedgehog-signaling

P. Heretsch, A. Büttner, L. Tzagkaroulaki, S. Zahn, B. Kirchner, A. Giannis— 2011

The combination of theoretical and computational studies with organic synthesis and biological investigations has led to exo-cyclopamine. This stable and highly potent derivative of cyclopamine promises big potential as an experimental drug against several types of human cancer.

Title8. Exo-Cyclopamine–a stable and potent inhibitor of hedgehog-signaling
AuthorP. Heretsch, A. Büttner, L. Tzagkaroulaki, S. Zahn, B. Kirchner, A. Giannis
Date2011
IdentifierDOI: 10.1039/C1CC11782C
Source(s)
CitationChem. Commun. 2011, 47, 7362-7364