15. Cyclopamine analogs bearing exocyclic methylenes are highly potent and acid-stable inhibitors of hedgehog signaling

J. Moschner, A. Chentsova, N. Eilert, I. Rovardi, P. Heretsch— 2013

The chemical synthesis and biological evaluation of new cyclopamine analogs bearing exocyclic methylenes in different positions is described. Bis-exo-cyclopamine 6 was identified as a potent inhibitor of the Gli1-dependent luciferase expression in Shh-LIGHTII cells. An extension of this study to F-ring-modified structures shows the necessity of a rigidly positioned nitrogen atom for bioactivity as well as the presence of the C21 methyl group for acid stability and bioactivity.

Title15. Cyclopamine analogs bearing exocyclic methylenes are highly potent and acid-stable inhibitors of hedgehog signaling
AuthorJ. Moschner, A. Chentsova, N. Eilert, I. Rovardi, P. Heretsch
Date2013
IdentifierDOI:10.3762/bjoc.9.267
Source(s)
CitationBeilstein J. Org. Chem. 2013, 9, 2328-2335.