13. General Synthetic Approach to Functionalized Dihydrooxepines

K.C. Nicolaou, R. Yu, L. Shi, Q. Cai, M. Lu, P. Heretsch— 2013

A three-step sequence to access functionalized 4,5-dihydrooxepines from cyclohexenones has been developed. This approach features a regioselective Baeyer–Villiger oxidation and subsequent functionalization via the corresponding enol phosphate intermediate.

Title13. General Synthetic Approach to Functionalized Dihydrooxepines
AuthorK.C. Nicolaou, R. Yu, L. Shi, Q. Cai, M. Lu, P. Heretsch
Date2013
IdentifierDOI: 10.1021/ol4006689
Source(s)
CitationOrg. Lett. 2013, 15, 1994-1997.