5. The First Total Synthesis of (+)-Ratjadone

U. Bhatt, M. Christmann, M. Quitschalle, E. Claus, M. Kalesse

The first total synthesis of ratjadone was achieved using a highly convergent approach joining three subunits together with a Wittig olefination and a selective Heck reaction as the pivotal steps. Besides establishing a robust and reliable route for the synthesis of this orphan ligand, the configuration of unknown stereocenters could also be determined. This synthesis not only provides an additional access to a biologically important compound but also enables the synthesis of structural analogues for biological target identification.

Title5. The First Total Synthesis of (+)-Ratjadone
AuthorU. Bhatt, M. Christmann, M. Quitschalle, E. Claus, M. Kalesse
IdentifierDOI: 10.1021/jo005768g
Source(s)
CitationJ. Org. Chem. 2001, 66, 1885-1893