48. Organophosphorus-mediated N–N bond formation: facile access to 3-amino-2H-indazoles

H. B. Abed, J. Schoene, M. Christmann, M. Nazaré

A convenient and efficient strategy has been devised to access 3-amino-2H-indazole derivatives in two steps from readily available starting materials. The conversion of 2-nitrobenzonitriles to substituted benzamidines followed by an organophosphorus-mediated reductive cyclization and a subsequent N–N bond formation afforded 3-amino-2H-indazoles in good to excellent yields.

Title48. Organophosphorus-mediated N–N bond formation: facile access to 3-amino-2H-indazoles
AuthorH. B. Abed, J. Schoene, M. Christmann, M. Nazaré
IdentifierDOI: 10.1039/C6OB01544A
Source(s)
CitationOrg. Biomol. Chem. 2016, 14, 8520-8528