36. Enantioselective Tandem Reactions at Elevated Temperatures: One-Pot Hydroformylation/SN1 Alkylation

J. Stiller, A. J. Vorholt, K. A. Ostrowski, A. Behr, M. Christmann

Canned heat: The optimization of a tandem sequence of a metal-catalyzed and a subsequent organocatalytic reaction is described (see figure). The tandem sequence was initially optimized toward a high yield by variations of substrate ratio, rhodium precursor, and ligands. The tandem reaction is also extendable to more complex alkenes and to substrates with additional functional groups.

Title36. Enantioselective Tandem Reactions at Elevated Temperatures: One-Pot Hydroformylation/SN1 Alkylation
AuthorJ. Stiller, A. J. Vorholt, K. A. Ostrowski, A. Behr, M. Christmann
IdentifierDOI: 10.1002/chem.201200639
Source(s)
CitationChem. Eur. J. 2012, 18, 9496-9499; (highlighted in Synfacts 2012, 8, 1094)