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35. Access to Skipped Polyene Macrolides by Ring Closing Metathesis: Total Synthesis of the RNA Polymerase Inhibitor Ripostatin B

P. Winter, W. Hiller, M. Christmann

Rip-Roaring! A convergent total synthesis of antibiotic ripostatin B was developed. A key step in the synthesis is a metathesis reaction allowing for a ring closure to the labile doubly skipped triene macrolide.

Title
35. Access to Skipped Polyene Macrolides by Ring Closing Metathesis: Total Synthesis of the RNA Polymerase Inhibitor Ripostatin B
Author
P. Winter, W. Hiller, M. Christmann
Identifier
DOI: 10.1002/anie.201108692
Citation
Angew. Chem. Int. Ed. 2012, 51, 3396–3400.