32. Total Synthesis and Biological Evaluation of (–)-Englerin A and B: Synthesis of Analogues with Improved Activity Profile

L. Radtke, M. Willot, H. Sun, S. Ziegler, S. Sauerland, C. Strohmann, R. Fröhlich, P. Habenberger, H. Waldmann, M. Christmann

The large-scale synthesis of englerin A and subsequent structure-activity relationship studies have led to the discovery of highly potent analogues.

Title32. Total Synthesis and Biological Evaluation of (–)-Englerin A and B: Synthesis of Analogues with Improved Activity Profile
AuthorL. Radtke, M. Willot, H. Sun, S. Ziegler, S. Sauerland, C. Strohmann, R. Fröhlich, P. Habenberger, H. Waldmann, M. Christmann
IdentifierDOI: 10.1002/anie.201007790
Source(s)
CitationAngew. Chem. Int. Ed. 2011, 50, 3998-4002