27. Enantioselective α- and γ-Alkylation of α,β-Unsaturated Aldehydes using Dienamine Activation

J. Stiller, E. Marqués-López, R. P. Herrera, R. Fröhlich, C. Strohmann, M. Christmann

The enantioselective alkylation of α,β-unsaturated aldehydes with stabilized carbocations as electrophiles via the activation as dienamine intermediates is described. This unique application of dienamine catalysis allows for the first enantioselective γ-alkylation of linear α,β-unsubstituted enals.

Title27. Enantioselective α- and γ-Alkylation of α,β-Unsaturated Aldehydes using Dienamine Activation
AuthorJ. Stiller, E. Marqués-López, R. P. Herrera, R. Fröhlich, C. Strohmann, M. Christmann
IdentifierDOI: 10.1021/ol102559f
Source(s)
CitationOrg. Lett. 2011, 13, 71-73