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25. Total synthesis: Towards artificial terpene cyclases

M. Willot, M. Christmann

The plant-derived sesquiterpene englerin A is a potent inhibitor of several renal cancer cell lines. Two recent total syntheses have utilized cationic gold(I)-complexes to coax readily available open-chain precursors into englerin's challenging oxotricyclic core with enzyme-like precision.

Title
25. Total synthesis: Towards artificial terpene cyclases
Author
M. Willot, M. Christmann
Identifier
DOI: 10.1038/nchem.715
Source(s)
Citation
Nature Chem. 2010, 2, 519–520.