22. Total Synthesis and Absolute Configuration of the Guaiane Sesquiterpene Englerin A

M. Willot, L. Radtke, D. Könning, R. Fröhlich, V. H. Gessner, C. Strohmann, M. Christmann

Catnip craze: Nepetalactone, the psychoactive ingredient of catmint, was selected as starting material for the first enantioselective synthesis of englerin A. This cytotoxic guaiane sesquiterpene is a highly selective inhibitor (1–87 nM) of several renal cancer cell lines. The absolute configuration of this natural product was determined by total synthesis.

Title22. Total Synthesis and Absolute Configuration of the Guaiane Sesquiterpene Englerin A
AuthorM. Willot, L. Radtke, D. Könning, R. Fröhlich, V. H. Gessner, C. Strohmann, M. Christmann
IdentifierDOI: 10.1002/anie.200905032
Source(s)
CitationAngew. Chem. Int. Ed. 2009, 48, 9105-9108; (highlighted in Synfacts 2010, 262; featured in: Chemical & Engineering News, 87(46), November 16, 2009.)