21. Crossed Intramolecular Rauhut-Currier-Type Reactions via Dienamine Activation

E. Marqués-López, R. P. Herrera, T. Marks, W. C. Jacobs, D. Könning, R. M. de Figueiredo, M. Christmann

The intramolecular Rauhut−Currier reaction creates a carbon−carbon bond between two tethered Michael acceptors. Previous asymmetric versions have relied on 1,4-additions of chiral nucleophilic catalysts. Herein, we investigate a novel strategy that involves the formation of electron rich dienamines as key intermediates. Our methodology provides an efficient entry to the iridoid framework.

Title21. Crossed Intramolecular Rauhut-Currier-Type Reactions via Dienamine Activation
AuthorE. Marqués-López, R. P. Herrera, T. Marks, W. C. Jacobs, D. Könning, R. M. de Figueiredo, M. Christmann
IdentifierDOI: 10.1021/ol901614t
Source(s)
CitationOrg. Lett. 2009, 11, 4116-4119; (highlighted in Synfacts 2009, 1276)