Teaching

(1) Lecture Course (VL 21242 and 21242b) (Calderon, Bertin) WS 2016-2017. Soft Matter v2.0 (4 SWS - 5 credits)

The underlying chemistry and biopharmaceutical principles and remaining challenges will be presented and discussed along with examples from the lab and every day life.

Mondays 14-18 h, room 23.02.

Starts on 17.10.2016

Program:

1st part:

  • Introduction:
    What is soft matter? What are the general aspects of soft matter? Why is it important?
  • Amphiphiles: Self-assembly of amphiphiles such as surfactants and block copolymers in bulk and solution (micelles, vesicles)
  • Gels: What is a gel? Applications of (hydro)gels for biomedical applications
  • Colloids
  • Liquid crystals
  • Soft Matter in Nature: Biomembranes, artificial cells, etc.
  • Self-healing polymers, Shape memory polymers for biomedical applications

2nd part:

  • Fundamentals:
    Forces, energies, and timescales in soft matter, A brief intro to phase transitions
  • Polymers:
    Introduction to polymers, Ideal chains, Real chains, Polymer thermodynamics, Viscoelasticity
  • Gels: Percolation theory, Swelling

During the first half of the semester (with S-Jun.-Prof. Annabelle Bertin, overview of the various types of soft matter, mostly from the chemical and materials cience point of view and for biomedical applications) the students will be asked to discuss reviews and publications as training for the exam and work in small groups (during the seminar itself). In the frame of the seminars (Übungen), during the second half of the semester (with S-Jun.-Prof. Marcelo Calderón, soft matter approached mostly from the physical chemistry point of view), the students will be asked to present one experimental method that is important in the field of Soft Matter (AFM, DLS, Zeta-Potential, Rheology, etc; the talks should be prepared at home).

The exam format will be a talk / ppt presentation about a recent publication (10-15 min) related to at least one of the topics studied during the course followed by 10-15 min questions by the two examiners, half on the topic of the publication, half on the lecture in general.


(2) Research Seminars. Functional Nanogels and Polymer-Drug Conjugates

 

Offered throughout the year in a group seminar context. Please enquire about registration to marcelo.calderon@fu-berlin.de or contact directly to some of the subgroup members. >> Details


(3) WS 2016-2017. Makro 2: Advanced Topics in Polymer Synthesis (21262a and b)

Schedule

Lecture 09.11.2016

Lecture 10.11.2016

Lecture 11.11.2016

Lecture 14.11.2016


(4) 21266a and 21266b (Calderon) WS 2016 - 2017. Polymeric and Macromolecular Therapeutic and Diagnostic Agents (4 SWS - 5 credits)


Thursdays, 14:00 – 18:00 hs, Room 36.07.

Course starts on 20.10.2016

 

Outline

Basics on drug classes for therapy and diagnostic imaging;

Basics on pathophysiology: genetic diseases, human viral diseases, cancer

Background on pharmacology, active and passive targeting in cancer therap

Classes of polymer therapeutics: polymeric drug or sequestrant, polymer-drug conjugates, polymer-protein conjugates

Multivalent macromolecular architectures: dendrimers, hyperbranched polymers, dendronized polymers & Multivalency as novel mode of action

Polymer based therapeutics such as gels (nanogels, hydrogels), nanospheres, microspheres.

Self assembled macromolecular/polymeric nanostructures: micelles formed by polymers and dendritic amphiphiles, vesicles made from phospholipids (liposomes), Janus dendrimers (dendrimersomes) or polymers (polymersomes), and other nanocapsules (LbL).

Polymers and macromolecules for gene therapy (concept of polyelectrolyte, polyion complexe micelles-PIC): dendriplexes, polyplexes.

Nanotheranostics, biological fate of polymeric particles.

Clinical approval of polymer therapeutics.

The exam will consist in a talk / ppt presentation about a recent publication (10-15 min) related to at least one of the topics studied during the course followed by 10-15 min questions, half on the topic of the publication, half on the lecture in general.

Moreover the students will be asked to discuss papers once during the lecture as training for the exam.


(5) Lecture Course (VL 21238) (Calderon, Bertin) SS 2016. Polymeric and inorganic bio(nano)materials for biomedical applications (5 credits)

The underlying chemistry and biopharmaceutical principles and remaining challenges will be presented and discussed along with examples from the lab and every day life.

Wednesdays 9-13 h, room 23.03.

Starts on 20.04.2016

Program:

- Principles of nanotechnology. Nanochemistry: Synthesis of soft and hard nanoparticles (metal, metal oxide, quantum dots, nanogels, core-shell systems, etc.).

- Chemical modifications of materials.

- Physicochemical/nanoscale characterization methods.

- Technological applications of soft/hard nanoparticles, hydrogels, biomaterials, especially for biomedical applications.

- Biopharmaceutical basics. In vivo fate of nanoparticles (biodistribution, cell internalization, nanotoxicity)

- Pulmonary Drug Delivery Targeting the brain, transdermal drug delivery, mucoadhesive drug delivery

- Applications of carbon-based nanoparticles: carbon nanotubes, graphene, etc.

- Interactions of materials with proteins and cells.

- Discussion of examples from literature and market.

(6) Research Seminars. Functional Nanogels and Polymer-Drug Conjugates

 

Offered throughout the year in a group seminar context. Please enquire about registration to marcelo.calderon@fu-berlin.de or contact directly to some of the subgroup members. >> Details

(7) WS 2015-2016. Methods in Polymer Synthesis


Talk 05.11.2015 -->>> Download

 

(8) 21233a and 21233b (Calderon) WS 2015 - 2016. Polymeric and Macromolecular Therapeutic and Diagnostic Agents (4 SWS - 5 credits)


Thursdays, 14:00 – 18:00 hs, Room 36.07. Course starts on 15.10.2015

 

Outline

Basics on drug classes for therapy and diagnostic imaging;

Basics on pathophysiology: genetic diseases, human viral diseases, cancer

Background on pharmacology, active and passive targeting in cancer therap

Classes of polymer therapeutics: polymeric drug or sequestrant, polymer-drug conjugates, polymer-protein conjugates

Multivalent macromolecular architectures: dendrimers, hyperbranched polymers, dendronized polymers & Multivalency as novel mode of action

Polymer based therapeutics such as gels (nanogels, hydrogels), nanospheres, microspheres.

Self assembled macromolecular/polymeric nanostructures: micelles formed by polymers and dendritic amphiphiles, vesicles made from phospholipids (liposomes), Janus dendrimers (dendrimersomes) or polymers (polymersomes), and other nanocapsules (LbL).

Polymers and macromolecules for gene therapy (concept of polyelectrolyte, polyion complexe micelles-PIC): dendriplexes, polyplexes.

Nanotheranostics, biological fate of polymeric particles.

Clinical approval of polymer therapeutics.

(9) Lecture Course (VL 21238) (Calderon, Bertin) SS 2015. Polymeric and inorganic bio(nano)materials for biomedical applications (5 credits)

The underlying chemistry and biopharmaceutical principles and remaining challenges will be presented and discussed along with examples from the lab and every day life.

Wednesdays 9-13 h, room 23.03.

Starts on 15.04.2015

The students will be expected to give a talk and write a paper.

Program:

- Principles of nanotechnology. Nanochemistry: Synthesis of soft and hard nanoparticles (metal, metal oxide, quantum dots, nanogels, core-shell systems, etc.).

- Chemical modifications of materials.

- Physicochemical/nanoscale characterization methods.

- Technological applications of soft/hard nanoparticles, hydrogels, biomaterials, especially for biomedical applications.

- Biopharmaceutical basics. In vivo fate of nanoparticles (biodistribution, cell internalization, nanotoxicity)

- Pulmonary Drug Delivery Targeting the brain, transdermal drug delivery, mucoadhesive drug delivery

- Applications of carbon-based nanoparticles: carbon nanotubes, graphene, etc.

- Interactions of materials with proteins and cells.

- Discussion of examples from literature and market.


(10) WS 2014-2015. Methods in Polymer Synthesis


Talk Polymer Therapeutics -->>> Download

Talk Polymer Nanoparticles -->>> Download


(11) 21 233 V (Bertin, Calderon) WS 2014 - 2015. Polymeric and Macromolecular Therapeutic and Diagnostic Agents (3 SWS)


Thursdays, 14:00 – 17:00 hs, Room 34.16/17. Course starts on 16.10.2014

 

 

Outline

Basics on drug classes for therapy and diagnostic imaging;

Basics on pathophysiology: genetic diseases, human viral diseases, cancer

Background on pharmacology, active and passive targeting in cancer therap

Classes of polymer therapeutics: polymeric drug or sequestrant, polymer-drug conjugates, polymer-protein conjugates

Multivalent macromolecular architectures: dendrimers, hyperbranched polymers, dendronized polymers & Multivalency as novel mode of action

Polymer based therapeutics such as gels (nanogels, hydrogels), nanospheres, microspheres.

Self assembled macromolecular/polymeric nanostructures: micelles formed by polymers and dendritic amphiphiles, vesicles made from phospholipids (liposomes), Janus dendrimers (dendrimersomes) or polymers (polymersomes), and other nanocapsules (LbL).

Polymers and macromolecules for gene therapy (concept of polyelectrolyte, polyion complexe micelles-PIC): dendriplexes, polyplexes.

Nanotheranostics, biological fate of polymeric particles.

Clinical approval of polymer therapeutics.


(12) 21 233 V (Calderon) WS 2013 - 2014. Polymer Therapeutics (3 credits)

 

 

Program:

1 Basics on drug classes (modes of action, chemical examples)
2 Background on biology and pharmacology (absorption, distribution, metabolism, excretion, toxicity)
3 Principles of drug delivery with polymers (drug transport, drug release)
4 Chemistry of polymers and macroarchitectures
5

Synthesis of bioconjugates (conjugation chemistry, linkers, reactive groups)

6 Multivalency /Polyvalency as novel mode of action.
7 Discussion of examples from literature and the market.
8 Basics on pharmaceutical drug development

 

(9) Introduction to macromolecular chemistry. 21 261a-V (Haag) WS 2013


Hyperbranched and Dendritic Polymers - 23.10.2013

Polymer Therapeutics - 05.11.2013


(13) 21238 (Bertin, Calderon, Haag) SS 2013

Chemical Nanotechnology (3 SWS)

Program:

1 Principles of nanotechnology
2 Nanochemistry: Synthesis of soft and hard nanoparticles (metal, metal oxide, quantum dots, nanogels, core-shell systems, etc.)
3 Chemical modifications of nanoparticles.
4 Physicochemical/nanoscale characterization methods for nanoparticles.
5

Technological applications of soft and hard nanoparticles, especially for biomedical applications.

6 Applications of carbon-based nanoparticles: carbon nanotubes, graphene, etc.
7 Interactions of nanoparticles with proteins and cells.
8 In vivo fate of nanoparticles (biodistribution, cell internalization, nanotoxicity)