Stricker_01_Grouplogo584x100

Publications

Original articles since 2006

 

2016

 

Knierim E, Hirata H, Wolf NI, Morales-Gonzalez S, Schottmann G, Tanaka Y, Rudnik-Schöneborn S, Orgeur M, Zerres K, Vogt S, van Riesen A, Gill E, Seifert F, Zwirner A, Kirschner J, Goebel HH, Hübner C, Stricker S, Meierhofer D, Stenzel W, Schuelke M. Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures. Am. J. Hum. Genet. 2016: 98(3) 473-89. doi: 10.1016/j.ajhg.2016.01.006

 

2015

 

Bourgeois A, Esteves de Lima J, Charvet B, Kawakami K, Stricker S, Duprez D. Stable and bicistronic expression of two genes in somite- and lateral plate-derived tissues to study chick limb development. BMC Dev. Biol. 2015: 15:39. doi: 10.1186/s12861-015-0088-3


Berkholz J, Orgeur M, Stricker S, Munz B. skNAC-and Smyd1 in transcriptional control. Exp. Cell Res. 2015: 336(2) 182-191

 

Maass PG, Aydin A, Luft FC, Schächterle C,Weise A, Stricker S, Lindschau C, Vaegler M, Qadri F, Toka HR, Schulz H, Krawitz PM, Hecht J, Hollfinger I, Wefeld-Neuenfeld Y, Bartels-Klein I, Mühl A, Kann M, Schuster H, Chitayat D, Bialer MG, Wienker TF, OttJ,Rittscher K, Liehr T, Jordan J, Plessis G, Tank J, Mai K, Naraghi R, Hodge R, Hopp M, Hattenbach LO, Busjahn A, Rauch A, Vandeput F, Gong M, Rüschendorf F, Hübner N, Haller H, Mundlos S, Bilginturan N, Movsesian MA, Klussmann E, Toka O, Bähring S. PDE3A mutations cause autosomal-dominant hypertension with brachydactyly. Nat. Genet. 2015: 47(6) 647-653

 

Pfirrmann T, Emmerich D, Ruokonen P, Auw-Hädrich C, Buchen R, Reinhard T, Fischer-Zirnsak B, Mundlos S, Klopocki E, Stricker S, Hecht J, Krawitz P, Hollemann T, Warman M, Spiekerkötter U, Lausch E, Zabel B, Hoffmann K, Villavicencio-Lorini P. Molecular Pathomechanism of X-linked Megalocornea: Novel Frameshift Mutation in the Stem Cell Niche Factor CHRDL1. Hum. Mol. Genet. 2015: 24(11) 3119-3132

 

2014

 

Yiang T, Bassuk AG, Stricker S, Fritzsche B. Prickle1 is necessary for the caudal migration of murine facial branchiomotor neurons. Cell Tiss. Res. 2014: 357(3) 349-361

 

Kuss P, Kraft K, Stumm J, Ibrahim D, Vallecillo-Garcia P, Mundlos S, Stricker S. Regulation of Cell Polarity in the Cartilage Growth Plate and Perichondrium of Metacarpal Elements by HOXD13 and WNT5A. Dev. Biol. 2014: 385(1), 83-93

 

2013

 

Sartori R, Schirwis E, Blaauw B, Bortolanza S, Zhao J, Enzo E, Stantzou A, Mouisel E, Toniolo L, Ferry A, Stricker S, Alfred L Goldberg AL, Dupont S, Piccolo S, Amthor H, Sandri M. BMP signaling controls muscle mass. Nat. Genet. 2013: 45(11), 1309-18

 

Jamsheer A, Zemojtel T, Kolanczyk M, Stricker S, Hecht J, Krawitz P, Doelken SC, Glazar R, Socha M, Mundlos S. Whole exome sequencing identifies FGF16 nonsense mutations as the cause of X-linked recessive metacarpal 4/5 fusion. J. Med. Genet. 2013: 50(9), 573-84

 

2012

 

Maas P, Rump A, Schulz H, Stricker S, Schulze L, Platzer K, Aydin A, Tinschert S, Brennan M, Luft FC, Bähring S. PTHLH and SOX9 dysregulation by a misplaced lncRNA causes brachydactyly. J. Clin. Invest. 2012: 122(11), 3990-4002.

 

Ott CE, Hein H, Lohan S, Hoogeboom J, Foulds N, Grünhagen J, Stricker S, Villavicencio-Lorini P, Klopocki E, Mundlos S. Microduplications upstream of MSX2 are associated with a phenocopy of cleidocranial dysplasia. J. Med. Genet. 2012: 49(7), 437-41.

 

Klopocki E. Lohan S. Doelken SC. Stricker S. Ockeloen CW. Soares Thiele de Aguiar R. Lezirovitz K. Mingroni Netto RC. Jamsheer A. Shah H. Kurth I. Habenicht R. Warman M. Devriendt K. Kordaß U. Hempel M. Rajab A. Mäkitie O. Naveed M. Radhakrishna U. Antonarakis SE. Horn D. Mundlos S. Duplications of BHLHA9 are associated with ectrodactyly and tibia hemimelia inherited in non-Mendelian fashion. J. Med. Genet. 2012: 49(2), 119-125. Epub Dec 6. 2011.

 

Stricker S, Mathia S, Haupt J, Seemann P, Meier J, Mundlos S. Odd-skipped related genes regulate differentiation of embryonic limb mesenchyme and bone marrow mesenchymal stromal cells. Stem Cells Dev. 2012: 21(4), 623-633. Epub Jul 26. 2011.

 

2011

 

Baasanjav S, Al-Gazali L, Hashiguchi T, Mizumoto S, Fischer B, Horn D, Seelow D, Ali BR,  Aziz SAA, Langer R, Saleh AAH, Becker C, Nürnberg G, Cantagrel V, Gleeson JG, Gomez D, Michel JB, Stricker S, Lindner TH, Nürnberg P, Sugahara K, Mundlos S, Hoffmann K. Faulty initiation of proteoglycan synthesis causes cardiac and joint defects. Am. J. Hum. Genet. 2011:89(1), 15-27

 

Kossler N*, Stricker S*, Rödelsperger C, Robinson PN Kim J, Dietrich C, Osswald M, Kühnisch J, Stevenson DA, Braun T, Mundlos S, Kolanczyk M. Neurofibromin (Nf1) is required for skeletal muscle development. Hum. Mol. Genet. 2011:20(14), 2697-709

*co-first authors

 

Klopocki E, Lohan S, Brancati F, Koll R, Brehm A, Seemann P, Dathe K, Stricker S, Hecht J, Bosse K, Betz RC, Garaci FG, Dallapiccola B, Jain M, Muenke M, Ng VCW, Chan W, Chan D, Mundlos S. Copy Number Variations (CNVs) involving the IHH locus are Associated with Syndactyly and Craniosynostosis. Am. J. Hum. Genet. 2011: 88(1), 70-75

 

2010

 

Brancati F, Fortugno P, Bottillo I, Lopez M, Josselin E, Boudghene-Stambouli O, Agolini E, Bernardini L, Bellacchio E, Iannicelli M, Rossi A, Dib-Lachachi A, Stuppia L, Palka G, Mundlos S, Stricker S, Kornak U, Zambruno G, Dallapiccola B. Mutations in PVRL4, encoding cell adhesion molecule nectin-4, cause ectodermal dysplasia-syndactyly syndrome. Am. J. Hum. Genet. 2010: 87(2), 265-73

 

Witte F, Chan D, Economides AN, Mundlos S, Stricker S. Receptor tyrosine kinase-like orphan receptor 2 (ROR2) and Indian hedgehog regulate digit outgrowth mediated by the phalanx-forming region. Proc. Natl. Acad. Sci. U.S.A.2010: 107(32), 14211-14216

 

Clayton P, Fischer B, Mann A, Mansour S, Rossier E, Veen M, Lang C, Baasanjav S, Kieslich M, Brossuleit K, Gravemann S, Schnipper N, Karbasyian M, Demuth I, Zwerger M, Vaya A, Utermann G, Mundlos S, Stricker S, Sperling K, Hoffmann K. Mutations causing greenberg dysplasia but not pelger anomaly uncouple enzymatic from structural functions of a nuclear membrane protein. Nucleus 2010: 1(4), 1-13

 

Witte F, Bernatik O, Kirchner K, Masek J, Mahl A, Krejci P, Mundlos S, Schambony A, Bryja V, Stricker S. Negative regulation of Wnt signaling by CK1 phosphorylated Dishevelled via Ror2. FASEB J. 2010: 24, 2417-2426

 

Jensen LR, Bartenschlager H, Rujirabanjerd S, Tzschach A, Numann A, Janecke AR, Sporle R, Stricker S, Raynaud M, Nelson J, Hackett A, Fryns JP, Chelly J, de Brouwer APM, Hamel B, Gecz J, Ropers HH,Kuss AW. A distinctive gene expression fingerprint in mentally retarded male patients reflects disease-causing defects in the histone demethylase KDM5C. PathoGenetics 2010: (3)2doi:10.1186/1755-8417-3-2

 

Liška F, Šnajdr P, Stricker S, Gosele C, Křenová D, Mundlos S, Hübner N. Impairment of Sox9 expression in limb buds of rats homozygous for hypodactyly mutation. Folia Biol. 2010: 56, 58-65

 

Maass PG, Wirth J, Aydin A, Rump A, Stricker S, Tinschert S, Otero M, Tsuchimochi K, Goldring MB, Luft FC, Bähring S. A cis-regulatory site downregulates PTHLH in translocation t(8;12)(q13;p11.2) and leads to Brachydactyly Type E. Hum Mol Genet. 2010: 19(5), 848-860

 

2009

 

Seemann P, Brehm A, König J, Reissner C, Stricker S, Kuss P, Haupt J, Renninger S, Nickel J, Sebald W, Groppe JC, Plöger F, Pohl J, Schmidt-von Kegler M, Walther M, Gassner I, Rusu C, Janecke AR, Dathe K, Mundlos S. Mutations in GDF5 Reveal a Key Residue Mediating BMP Inhibition by NOGGIN.PLOS Genet. 2009: 5(11), e1000747

 

Verhey van Wijk N, Witte F, Feike AC, Schambony A, Birchmeier W, Mundlos S, Stricker S. The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling. Biochem. Biophys. Res. Commun. 2009: 390, 211-216

 

Schwarzer W, Witte F, Rajab A, Mundlos S, Stricker S. A gradient of ROR2 protein stability and membrane localization confers brachydactyly type B or Robinow syndrome phenotypes. Hum. Mol. Genet. 2009: 18(21), 4013-4021

 

Kurth I, Klopocki E, Stricker S, van Oosterwijk J, Vanek S, Altmann J, van Harssel J, de Ravel T, Wilkie A, Gal A, Mundlos S. Duplications of non-coding elements 5´ of SOX9 are associated with brachydactyly/anonychia. Nat. Genet. 2009: 41(8), 862-863

 

Gao B, Hu J, Stricker S, Cheung M, Ma G, Law KF, Witte F, Briscoe J, Mundlos S, He L, Cheah KSE, Chan D. A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range. Nature 2009: 458(7242), 1196-1201

 

Witte F, Dokas J, Neuendorf F, Mundlos S, Stricker S. Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation. Gene Expr. Patterns 2009: 9, 215-223

             awarded “Top 10 cited article 2008 – 2010”; awarded “Top 5 cited article 2009 - 2013”

2008

 

Winkel A, Stricker S, Tylzanowski P, Seiffart V, Mundlos S, Gross G, Hoffmann A. Wnt-ligand-dependent interaction of TAK1 (TGF-beta-activated kinase-1) with the receptor tyrosine kinase Ror2 modulates canonical Wnt-signalling. Cell. Signal. 2008: 20(11), 2134-2144

 

Steichen-Gersdorf E, Gaßner I, Superti-Furga A, Ullmann R, Stricker S, Klopocki E, Mundlos S. Triangular tibia with fibular aplasia associated with a microdeletion on 2q11.2 encompassing LAF4. Clin. Genet. 2008: 74(6), 560-565

 

Raz R, Stricker S, Gazzerro E, Clor JL, WitteF, Nistala H, Zabski S, Pereira RC, Stadmeyer L, Wang X, Gowen L, Sleeman MW, Yancopoulos GD, Canalis E, Mundlos S, Valenzuela DM, Economides AN. The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints, and modeling recessive Robinow syndrome. Development 2008: 135, 1713-1723

 

Hecht J, Stricker S, Wiecha U, Stiege A, Panopoulou G, Podsiadlowski L, Poustka AJ, Dieterich C, Ehrich S, Suvorova J, Mundlos S, Seitz V. Evolution of a Core Gene Network for Skeletogenesis in Chordates. PLOS Genetics 2008: 4(3), e1000025

 

Michalk A*, Stricker S*, Becker J, Rupps R, Pantzar T, Miertus J, Botta G, Naretto VG, Janetzki C, Yaqoob N, Ott CE, Seelow D, Wieczorek D, Fiebig B, Wirth B, Hoopmann M, Walther M, Körber F, Blankenburg M, Mundlos S, Heller R, Hoffmann K. Acetylcholine receptor pathway mutations explain various fetal akinesia deformation sequence disorders. Am. J. Hum. Genet. 2008: 82(2), 464-476

*co-first authors

 

2007

 

Reijntjes S, Stricker S, Mankoo BS. A Comparative Analysis of Meox1 and Meox2 in the Developing Somite and Limb of the Chick Embryo. Int. J. Dev. Biol. 2007: 51(8), 753-759

 

19.       Kolanczyk M, Kossler N, Kühnisch J, Lavitas L, Stricker S, Wilkening U, Manjubala I, Fratzl P, Spörle R, Herrmann BG, Parada L, Kornak U, Mundlos S. Multiple Roles for Neurofibromin in Skeletal Development and Growth. Hum. Mol. Genet. 2007 : 16(8), 874-886

 

18.       Hecht J, Seitz V, Urban M, Wagner F, Robinson PN, Stiege A, Dieterich C, Kornak U, Wilkening U, Brieske N, Zwingman C, Kidess A, Stricker S, Mundlos S. Detection of novel skeletogenesis target genes by comprehensive analysis of a Runx2-/- mouse model. Gene Expr. Patterns 2007: 7, 102-112

 

2006

 

Stricker S#, Verhey van Wijk N, Witte F, Brieske N, Seidel K and Mundlos S. Cloning and Expression Pattern of Chicken Ror2 and Functional Characterization of Truncating Mutations in Brachydactyly Type B and Robinow Syndrome. Dev. Dyn. 2006: 235(12), 3456-65

             #corresponding author

 

Guo G, Booms P, Halushka M, Dietz HC, Ney A, Stricker S, Hecht J, Mundlos S, Robinson, P.N. Induction of macrophage chemotaxis by aortic extracts of the mgR Marfan mouse model and a GxxPG-containing fibrillin-1 fragment. Circulation 2006: 114(17), 1855-62

 

Woods CG*, Stricker S*, Seemann P, Stern R, Cox J, Sherridan E, Roberts E, Springell K, Scott S, Karbani G, Sharif SM, Toomes C, Bond J, Kumar D, Al-Gazali L, Mundlos S. The specific importance of WNT7A in human limb development. Am. J. Hum. Genet. 2006: 79(2), 402-408

*co-first authors

 

Hoffmann K, Müller JS, Stricker S, Megarbane A, Rajab A, Lindner TH, Cohen M, Chouery E, Adaimy L, Ghanem I, Delague V, Boltshauser E, Talim B, Horvath R, Robinson PN, Lochmüller H, Hübner C, Mundlos S. Escobar Syndrome is a prenatal myasthenia caused by disruption of the acetylcholine receptor fetal gamma subunit. Am. J. Hum. Genet. 2006: 79(2), 303-12

 

Koch M, Veit G, Stricker S, Bhatt P, Kutsch S, Zhou P, Reinders E, Hahn RA, Song R, Burgeson RE, Gerecke DR, Mundlos S., Gordon, M.K. Expression of type XXIII collagen mRNA and protein. J. Biol. Chem. 2006: 281(30), 21546-21557

 

Stricker S#, Brieske N, Haupt J, Mundlos S. Comparative expression pattern of Odd-skipped related genes Osr1 and Osr2 in chick embryonic development. Gene Expr. Patterns 2006: 6(8), 826-34

#corresponding author

 

Zemojtel T, Kolanczyk M, Kossler N, Stricker S, Lurz R, Mikula I, Duchniewicz M, Schuelke M, Ghafourifar P, Martasek P, Vingron M, Mundlos S. Mammalian mitochondrial nitric oxide synthase: Characterization of a novel candidate. FEBS Lett. 2006: 580(2), 455-462

 

 

 

Reviews and book chapters

 

Spielmann M and Stricker S. Limb Development. In: Inborn Errors of Development (Ed. C.J. Epstein, R.P. Erickson, A. Wynshaw-Boris), Oxford University Press 2013 in press

 

Stricker S and Mundlos S. Development of the Limbs. In: Limb Malformations (S. Mundlos, D. Horn), Springer Verlag Berlin Heidelberg, 2014: 2-9

 

Stricker S, Mundlos S. FGF and ROR2 receptor tyrosine kinase signaling in human skeletal development. In: Carmen Birchmeier, editor: Curr. Top. Dev. Biol. Vol. 97 (Growth Factors in Development), Burlington: Academic Press, 2011: 179-206

 

Stricker S, Mundlos S. Mechanisms of digit formation: human malformation syndromes tell the story. Dev. Dyn. (Special issue “limb development” Ed. J. F. Fallon) 2011: 240(5), 990-1004