Dr. rer. nat. Christian Hiepen

Chris obtained a BSc and a MSc in Molecular Biology from the University of Applied Science Gelsenkirchen. During and in between his studies he worked for Artemis Pharmaceuticals generating novel and innovative RNAi-based gene targeting in mice. Chris performed his Master thesis in the Cell Signalling lab of Prof. Bart Vanhaesebroeck at QMUL London, working on distinct roles of Class IA PI3K isoforms in angiogenesis. He subsequently became a fellow of the Berlin-Brandenburg School for Regenerative Therapies (BSRT, DFG Graduate School 203) and joined the Lab of Prof. Petra Knaus in October 2008. Chris completed his PhD in November 2013 with the title “BMP2-induced PI3K signalling in directional cell migration – from molecular pathway to cellular function-“ with summa cum laude.

His current aim as postdoctoral researcher (BSRT associated Postdoctoral Fellow) is to understand the crosstalk of BMP signalling and mechanotransduction using advanced light-microscopy techniques.

Chris is member of the German Society of Cell Biology (DGZ) as well as Gesellschaft deutscher Chemiker (GDCh)

Dr. Christian Hiepen



Field of Activity

Signal Transduction

Telephone +49-30-838-52949
Fax +49-30-838-52936
Email christian.hiepen (at) / hiepenhome (at)
  • Bone morphogenetic protein signaling in bone homeostasis. Sánchez-Duffhues G, Hiepen C, Knaus P, Ten Dijke P. Bone. 2015 Jun 5.

  • Nanoscale control of surface immobilized BMP-2: toward a quantitative assessment of BMP-mediated signaling events. Schwab EH, Pohl TL, Haraszti T, Schwaerzer GK, Hiepen C, Spatz JP, Knaus P, Cavalcanti-Adam EA. Nano Lett. 2015 Mar 11

  • BMP2-induced chemotaxis requires PI3K p55γ/p110α-dependent phosphatidylinositol (3,4,5)-triphosphate production and LL5β recruitment at the cytocortex. Hiepen C, Benn A, Denkis A, Lukonin I, Weise C, Boergermann JH, Knaus P. BMC Biol. 2014 May 30;12:43. doi: 10.1186/1741-7007-12-43.

  • Kopf J, Paarmann P, Hiepen C, Horbelt D and Knaus P. BMP growth factor signaling in a biomechanical context, Biofactors 2013.

  • Ruschke K*, Hiepen C*, Becker J, Knaus P. BMPs are mediators in tissue crosstalk of the regenerating musculoskeletal system. Cell Tissue Res. 2012 Mar; 347(3):521-44. doi: 10.1007/s00441-011-1283-6. Epub 2012 Feb 12. * equal contribution
  • Schwaerzer GK, Hiepen C, Schrewe H, Nickel J, Ploeger F, Sebald W, Mueller T, Knaus P. New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance. J Bone Miner Res. 2012 Feb; 27(2):429-42. doi: 10.1002/jbmr.532.
  • Sieber C, Kopf J, Hiepen C, Knaus P. Recent advances in BMP receptor signaling. Cytokine Growth Factor Rev. 2009 Oct-Dec; 20(5-6):343-55. doi: 10.1016/j.cytogfr.2009.10.007. Epub 2009 Nov 7.