2024

• Ilhan M., Hastar N., Kampfrath B., Spierling D. N., Jatzlau J., Knaus P..BMP Stimulation Differentially Affects Phosphorylation and Protein Stability of β-Catenin in Breast Cancer Cell Lines. Int. J. Mol. Sci. 2024, 25(9), 4593; https://doi.org/10.3390/ijms25094593

• Noom, A., Sawitzki, B., Knaus, P. Duda, G.. A two-way street – cellular metabolism and myofibroblast contraction. npj Regen Med 9, 15 (2024). https://doi.org/10.1038/s41536-024-00359-x
• Raaz L., Mendez P.L., Mundlos S., Knaus P., Jatzlau J., Protocol for chromatin accessibility profiling of human endothelial cells cultured under fluid shear stress using ATAC-seq.STAR Protoc. 2024 Feb 7;5(1):102859. DOI: 10.1016/j.xpro.2024.102859. Online ahead of print. PMID: 38329877

• Szilágyi S.S., Burdzinski W., Jatzlau J., Ehrlich M., Knaus P., Henis Y.I.,

  The Activation of the Fibrodysplasia Ossificans Progressiva-Inducing ALK2-R206H Mutant Depends on the Distinct Homo-Oligomerization Patterns of ACVR2B and ACVR2A. Cells. 2024 Jan 25;13(3):221. DOI: 10.3390/cells13030221. PMID: 38334613

2023

• Dazzi, C., Mehl, J., Benamar, M., Gerhardt, H., Knaus, P., Duda, G.N., Checa S.,
  External mechanical loading overrules cell-cell mechanical communication in sprouting angiogenesis during early bone regeneration, PLoS Comput Biol (2023), DOI:https://doi.org/10.1371/journal.pcbi.1011647

• Jatzlau, J., Mendez, P.-L., Altay, A., Raaz, L., Zhang, Y., Mähr, S., Sesver,
  A., Reichenbach, M., Mundlos, S., Vingron, M., Knaus, P., Fluid Shear Stress-modulated chromatin
  accessibility reveals the mechano-dependency of endothelial SMAD1/5-mediated gene transcription,
  ISCIENCE (2023), DOI: https://doi.org/10.1016/j.isci.2023.107405
• Trumpp, M., Tan, W.H., Burdzinski, W., Basler, Y., Jatzlau, J., Knaus, P., Christoph Winkler,  Characterization of Fibrodysplasia Ossificans Progessiva relevant Acvr1/Acvr2 Activin receptors in medaka (Oryzias latipes) PLOS ONE (2023), DOI: https://doi.org/10.1371/journal.pone.0291379
• Großmann, N.Z., Hildebrandt, S., Morhart, R., Kallinich, T., Semler, O., Knaus, P., Fibrodysplasia ossificans progressiva – wenn sich plötzlich Knochen im Muskel bilden. Monatsschr Kinderheilkd (2023). DOI: https://doi.org/10.1007/s00112-023-01816-5

• Melo, U. S., Jatzlau, J., Prada-Medina, C. A., Flex, E., Hartmann, S., Ali, S., Schöpflin, R., Bernardini, L., Ciolfi, A., Moeinzadeh, M. H., Klever, M.-K., Altay, A., Vallecillo-García, P., Carpentieri, G., Delledonne, M., Ort, M.-J., Schwestka, M., Ferrero, G. B., Tartaglia, M., Brusco, A., Gossen, M., Strunk, D., Geißler, S., Mundlos, S., Stricker, S., Knaus, P., Giorgio, E., & Spielmann, M. (2023). Enhancer hijacking at the ARHGAP36 locus is associated with connective tissue to bone transformation. Nat Commun, 14(1), 2034. DOI:10.1038/s41467-023-37585-8

• Kotsaris, G., Qazi, T. H., Bucher, C. H., Zahid, H., Pöhle-Kronawitter, S., Ugorets, V., Jarassier, W., Börno, S., Timmermann, B., Giesecke-Thiel, C., Economides, A. N., Le Grand, F., Vallecillo-García, P., Knaus, P., Geissler, S., & Stricker, S. (2023). Odd skipped-related 1 controls the pro-regenerative response of fibro-adipogenic progenitors. NPJ Regen Med, 8(1), 19. DOI:10.1038/s41536-023-00291-6

• Quist-Løkken, I., Andersson-Rusch, C., Kastnes, M.H., Kolos, J.M., Jatzlau, J., Hella, H., Olsen, O.E., Sundan, A., Knaus, P., Hausch, F., Holien, T. FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells. Cell Commun Signal 21, 25 (2023). DOI: 10.1186/s12964-022-01033-9

     Please click here for a summary video!

• Jatzlau, J. & Burdzinski, W., Trumpp, M., Obendorf, L., Roßmann, K., Ravn, K., Hyvönen, M., Bottanelli, F., Broichhagen, J., Knaus, P., A versatile Halo- and SNAP-tagged BMP/TGFβ receptor library for quantification of cell surface ligand binding. Commun Biol. 2023 Jan 12. DOI: 10.1038/s42003-022-04388-4

2022

• Trumpp, M.; Oliveras-Martinez, A.; Gonschior, H.; Ast, J.; Hodson, D.J.; Knaus, P.; Lehmann, M.; Birol, M.; Broichhagen, J.; Enzyme self-label-bound ATTO700 in single molecule and superresolution microscopy. Chemical Communications. 2022 Nov 21. DOI:10.1039/d2cc04823j

• Mendez, P.L, Obendorf, L., Jatzlau, J., Burdzinski, W., Reichenbach, M., Nageswaran, V., Haghikia, A., Stangl, V., Hiepen, C., Knaus, P., Atheroprone fluid shear stress-regulated ALK1-Endoglin-SMAD signaling originates from early endosomes. BMC Biol. 2022 Sep 28;20(1):210. doi: 10.1186/s12915-022-01396-y.
• Geisthoff, U., Mahnken, A.H., Knaus, P. et al. Interdisziplinäres Management extrakranieller Gefäßanomalien. HNO 70, 380–388 (2022). https://doi.org/10.1007/s00106-022-01163-z

2021

• de Ruiter, R. D., Smilde, B. J., Pals, G., Bravenboer, N., Knaus, P., Schoenmaker, T., Botman, E., Sánchez-Duffhues, G., Pacifici, M., Pignolo, R. J., Shore, E. M., van Egmond, M., Van Oosterwyck, H., Kaplan, F. S., Hsiao, E. C., Yu, P. B., Bocciardi, R., De Cunto, C. L., Longo Ribeiro Delai, P., de Vries, T. J., Hilderbrandt, S., Jaspers, R. T., Keen, R., Koolwijk, P., Morhart, R., Netelenbos, J. C., Rustemeyer, T., Scott, C., Stockklausner, C., ten Dijke, P., Triffit, J., Ventura, F., Ravazzolo, R., Micha, D., & Eekhoff, E. M. W. (2021). Fibrodysplasia Ossificans Progressiva: What Have We Achieved and Where Are We Now? Follow-up to the 2015 Lorentz Workshop. Frontiers in Endocrinology, 12(1306).

• Kolos, J.M., Pomplun S., Jung S., Rieß B., Purder P.L., Voll A.M., Merz S., Gnatzy M., Geiger T.M., Quist-Løkken I., Jatzlau J., Knaus P., Holien T., Bracher A., Meyners C., Czodrowski P., Krewald V., Hausch F. Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3.1] aza-amides. Chem. Sci., 2021,12, 14758-14765, doi: 10.1039/d1sc04638a

• Mendez, P. L., Obendorf, L., Knaus, P. Visualization and Quantification of TGFβ/BMP/SMAD Signaling under Different Fluid Shear Stress Conditions using Proximity-Ligation-Assay. J. Vis. Exp. (175), e62608, doi:10.3791/62608 (2021).

• Heinks T, Hettwer A, Hiepen C, Weise C, Gorka M, Knaus P, Mueller TD, Loidl-Stahlhofen A. Optimized expression and purification of a soluble BMP2 variant based on in-silico design. Protein Expr Purif. 2021 May;186 105918. doi:10.1016/j.pep.2021.105918.

• Reichenbach, M.; Mendez, P.-L.; da Silva Madaleno, C.; Ugorets, V.; Rikeit, P.; Boerno, S.; Jatzlau, J.; Knaus, P. Differential Impact of Fluid Shear Stress and YAP/TAZ on BMP/TGF‐β Induced Osteogenic Target Genes. Advanced Biology (2021). https://doi.org/10.1002/adbi.202000051

• Hildebrandt, S., Kampfrath, B., Fischer, K. Hildebrand, L. Haupt, J. Stachelscheid, H. and Knaus, P. ActivinA Induced SMAD1/5 Signaling in an iPSC Derived EC Model of Fibrodysplasia Ossificans Progressiva (FOP) Can Be Rescued by the Drug Candidate Saracatinib. Stem Cell Rev and Rep (2021). https://doi.org/10.1007/s12015-020-10103-9

2020

• Hiepen, C.; Mendez, P.-L.; Knaus, P. It Takes Two to Tango: Endothelial TGFβ/BMP Signaling Crosstalk with Mechanobiology. Cells 2020, 9, 1965.
• Fontana F, Haack T, Reichenbach M, Knaus P, Puceat M, Abdelilah-Seyfried S. Antagonistic Activities of Vegfr3/Flt4 and Notch1b Fine-tune Mechanosensitive Signaling during Zebrafish Cardiac Valvulogenesis. Cell Rep. 2020;32(2):107883. doi:10.1016/j.celrep.2020.107883
• da Silva Madaleno, C., Jatzlau, J. and Knaus, P. (2020). BMP signalling in a mechanical context - Implications for bone biology. Bone: doi.org/10.1016/j.bone.2020.115416
• Hiepen C., Jatzlau J., Knaus P. (2020). Biomechanical stress provides a second hit in the establishment of BMP/TGFβ-related vascular disorders. Cell Stress 2020, Jan 20;4(2):44-47. doi: 10.15698/cst2020.02.213.

2019

• Brunner P, Hastar N, Kaehler C, Burdzinski W, Jatzlau J, Knaus P. AMOT130 drives BMP-SMAD signaling at the apical membrane in polarized cells. Mol Biol Cell. 2019 Dec 4. doi: 10.1091/mbc.E19-03-0179
• Hiepen C, Jatzlau J, Hildebrandt S, Kampfrath B, Goktas M, Murgai A, Camacho JLC, Haag R, Ruppert C, Sengle G, Cavalcanti-Adam EA, Blank KG, Knaus P. BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics PLoS Biol. 2019 Dec 11. doi: doi.org/10.1371/journal.pbio.3000557
• Lorenz M, Blaschke B, Benn A, Hammer E, Witt E, Kirwan J, Fritsche-Guenther R, Gloaguen Y, Bartsch C, Vietzke A, Kramer F, Kappert K, Brunner P, Nguyen HG, Dreger H, Stangl K, Knaus P, Stangl V. Sex-specific metabolic and functional differences in human umbilical vein endothelial cells from twin pairs. Atherosclerosis. 2019 Oct 10;291:99-106. doi: 10.1016/j.atherosclerosis.2019.10.007. [Epub ahead of print]
• Salah E, Chatterjee D, Beltrami A, Tumber A, Preuss F, Canning P, Chaikuad A, Knaus P, Knapp S, Bullock AN, Mathea S. Lessons from LIMK1 enzymology and their impact on inhibitor design. Biochem J BCJ20190517. doi: https://doi.org/10.1042/BCJ20190517
• Differ C, Klatte-Schulz F, Bormann N, Minkwitz S, Knaus P, Wildemann B. Is NO the Answer? The Nitric Oxide Pathway Can Support Bone Morphogenetic Protein 2 Mediated Signaling. Cells 2019, 8(10), 1273; https://doi.org/10.3390/cells8101273 (registering DOI)
• Schreivogel S, Kuchibhotla V, Knaus P, Duda GN, Petersen A. Load-induced osteogenic differentiation of mesenchymal stromal cells is caused by mechano-regulated autocrine signaling. J Tissue Eng Regen Med. 2019 Jul 30. doi: 10.1002/term.2948. [Epub ahead of print]

2018

• Puts R, Rikeit P, Ruschke K, Knaus P, Schreivogel S, Raum K. Functional regulation of YAP mechanosensitive transcriptional coactivator by Focused Low-Intensity Pulsed Ultrasound (FLIPUS) enhances proliferation of murine mesenchymal precursors. PLoS One. 2018 Oct 26;13(10):e0206041. doi: 10.1371/journal.pone.0206041. eCollection 2018
• Chatzifrangkeskou M, Yadin D, Marais T, Chardonnet S, Cohen-Tannoudji M, Mougenot N, Schmitt A, Crasto S, Di Pasquale E, Macquart C, Tanguy Y, Jebeniani I, Pucéat M, Morales Rodriguez B, Goldmann WH, Dal Ferro M, Biferi MG, Knaus P, Bonne G, Worman HJ, Muchir A. Cofilin-1 phosphorylation catalyzed by ERK1/2 alters cardiac actin dynamics in dilated cardiomyopathy caused by lamin A/C gene mutation. Hum Mol Genet. 2018 Jun 5. doi: 10.1093/hmg/ddy215
• Olsen OE, Sankar M, Elsaadi S, Hella H, Buene G, Darvekar SR, Misund K, Katagiri T, Knaus P, Holien T BMPR2 inhibits activin- and BMP-signaling via wild type ALK2. J Cell Sci. 2018 May 8. pii: jcs.213512. doi: 10.1242/jcs.213512. [Epub ahead of print]; PMID: 29739878
• Chan WL, Steiner M, Witkos T, Egerer J, Busse B, Mizumoto S, Pestka JM, Zhang H, Hausser I, Khayal LA, Ott CE, Kolanczyk M, Willie B, Schinke T, Paganini C, Rossi A, Sugahara K, Amling M, Knaus P, Chan D, Lowe M, Mundlos S, Kornak U Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica. PLoS Genet. 2018 Mar 21;14(3):e1007242. doi: 10.1371/journal.pgen.1007242
• Strasen J, Sarma U, Jentsch M, Bohn S, Sheng C, Horbelt D, Knaus P, Legewie S, Loewer A. Cell‐specific responses to the cytokine TGFβ are determined by variability in protein levels. Mol Syst Biol. (2018) 14: e7733. doi: 10.15252/msb.20177733.

2017

• Schreiber I, Dörpholz G, Ott CE, Kragesteen B, Schanze N, Lee CT, Köhrle J, Mundlos S, Ruschke K, Knaus P. BMPs as new insulin sensitizers: enhanced glucose uptake in mature 3T3-L1 adipocytes via PPARγ and GLUT4 upregulation. Sci Rep. 2017 Aug 18;7(1):8778. doi: 10.1038/s41598-017-08676-6.
• Dörpholz G, Murgai A, Jatzlau J, Horbelt D, Belverdi MP, Heroven C, Schreiber I, Wendel G, Ruschke K, Stricker S, Knaus P. IRS4, a novel modulator of BMP/Smad and Akt signalling during early muscle differentiation. Sci Rep. 2017 Dec 8;7(1):17192. doi: 10.1038/s41598-017-17595-5.
• Benn A, Hiepen C, Osterland M, Schütte C, Zwijsen A, Knaus P. Role of bone morphogenetic proteins in sprouting angiogenesis: differential BMP receptor-dependent signaling pathways balance stalk vs. tip cell competence. FASEB J. 2017 Jul 21. DOI: 10.1096/fj.201700193RR.
• Stricker S, Knaus P, Simon HG. Putting Cells into Context. Front Cell DevBiol. 2017 Apr 5;5:32. doi: 10.3389/fcell.2017.00032.
• Migliorini E, Horn P, Haraszti T, Wegner SV, Hiepen C, Knaus P, Richter RP, Cavalcanti-Adam EA. Enhanced Biological Activity of BMP-2 Bound to Surface-Grafted Heparan Sulfate. Adv Biosyst. 2017 Mar, 1600041. DOI: 10.1002/adbi.201600041.
• Zhukova Y, Hiepen C, Knaus P, Osterland M, Prohaska S, Dunlop JWC, Fratzl P, Skorb EV. The Role of Titanium Surface Nanostructuring on Preosteoblast Morphology, Adhesion, and Migration. Adv Healthcare Mater. 2017 Mar, 1601244. DOI: 10.1002/adhm.201601244.
• Benn A, Haupt J, Hildebrandt S, Kaehler C, Knaus P. Physiological and Pathophysiological Consequences of Vascular BMP Signaling. Book chapter in: Vukicevic S/ Sampath KT. Bone Morphogenetic Proteins: Systems Biology Regulators. 367-407, Springer 2017 Mar. DOI: 10.1007/978-3-319-47507-3-17.

2016

• Sánchez-Duffhues G, Hiepen C, Knaus P, Ten Dijke P. Emerging regulators of BMP bioavailability. Bone. 2016 Dec;93:220-221. doi: 10.1016/j.bone.2016.01.022.
• Klatte-Schulz F, Giese G, Differ C, Minkwitz S, Ruschke K, Puts R, Knaus P, Wildemann B. An investigation of BMP-7 mediated alterations to BMP signalling components in human tenocyte-like cells. Sci Rep. 2016 Jul 11;6:29703. doi: 10.1038/srep29703.
• Puts R, Rikeit P, Ruschke K, Kadow-Romacker A, Hwang S, Jenderka KV, Knaus P, Raum K. Activation of Mechanosensitive Transcription Factors in Murine C2C12 Mesenchymal Precursors by Focused Low-Intensity Pulsed Ultrasound (FLIPUS). IEEE Trans Ultrason Ferroelectr Freq Control. 2016 Jul 7.
• Ruschke K, Meier C, Ullah M, Michaela Krebs AC, Silberreis K, Kohl B, Knaus P, Jagielski M, Arens S, Schulze-Tanzil G. Bone morphogenetic protein 2 / SMAD signalling in human ligamentocytes of degenerated and aged anterior cruciateligaments. Osteoarthritis Cartilage. 2016 May 18. doi: 10.1016/j.joca.2016.05.014.
• Paarmann P, Dörpholz G, Fiebig J, Amsalem AR, Ehrlich M, Henis YI, Müller T, Knaus P. Dynamin-dependent endocytosis of Bone Morphogenetic Protein2 (BMP2) and its receptors is dispensable for the initiation of Smad signaling. Int J BiochemCell Biol. 2016 Apr 22. doi: 10.1016/j.biocel.2016.04.010. Editor's pick May 2017 at World Biomedical Frontiers.
• Kopf J, Ulasevich S, Baidukova O, Zhukova Y, Dunlop JWC, Fratzl P, Rikeit P, Knaus P, Poznyak SK, Andreeva DV, Skorb EV. Ultrasonically Produced Porous Sponge Layer on Titanium to Guide Cell Behavior. Adv. Eng. Mater. 2016 Apr. 18: 476–483. doi: 10.1002/adem.201500456
• Fischer M, Rikeit P, Knaus P, Coirault C. YAP-mediated mechanotransduction in Skeletal Muscle. Front Physiol. 2016 Feb 16;7:41. doi: 10.3389/fphys.2016.00041.eCollection 2016.

• CGFR Special Issue: Bone/Body Morphogenetic Proteins edited by Petra Knaus:
  • Hiepen C, Yadin D, Rikeit P, Dörpholz G, Knaus P. Actions from head to toe: An update on Bone/Body Morphogenetic Proteins in health and disease. Cytokine Growth Factor Rev. 2016 Feb;27:1-11. doi: 10.1016/j.cytogfr.2015.12.006
  • García de Vinuesa A, Abdelilah-Seyfried S, Knaus P, Zwijsen A, Bailly S. BMP signaling in vascular biology and dysfunction. Cytokine Growth Factor Rev. 2016 Feb;27:65-79. doi: 10.1016/j.cytogfr.2015.12.005
  • Yadin D, Knaus P, Mueller TD. Structural insights into BMP receptors: Specificity, activation and inhibition. Cytokine Growth Factor Rev. 2016 Feb;27:13-34. doi: 10.1016/j.cytogfr.2015.11.005

• Amsalem AR, Marom B, Shapira KE, Hirschhorn T, Preisler L, Paarmann P, Knaus P, Henis YI, Ehrlich M. Differential regulation of translation and endocytosis of alternatively spliced forms of the type II bone morphogenetic protein (BMP) receptor. Mol Biol Cell. 2016 Feb 15;27(4):716-30. doi: 10.1091/mbc.E15-08-0547
• Benn A, Bredow C, Casanova I, Vukičević S, Knaus P. VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling. J Cell Sci. 2016 Jan 1;129(1):206-18. doi: 10.1242/jcs.179960
• Puts R, Ruschke K, Ambrosi TH, Kadow-Romacker A, Knaus P, Jenderka KV, Raum K. A Focused Low-Intensity Pulsed Ultrasound (FLIPUS) System for Cell Stimulation: Physical and Biological Proof of Principle. IEEE Trans Ultrason Ferroelectr Freq Control. 2016 Jan;63(1):91-100. doi: 10.1109/TUFFC.2015.2498042

2015

• Sánchez-Duffhues G, Hiepen C, Knaus P, Ten Dijke P. (2015) Bone morphogenetic protein signaling in bone homeostasis. Bone. 2015 Jun 4. pii: S8756-3282(15)00206-9
• Schwab EH, Pohl TL, Haraszti T, Schwaerzer GK, Hiepen C, Spatz JP, Knaus P, Cavalcanti-Adam EA. (2015) Nanoscale Control of Surface Immobilized BMP-2: Toward a Quantitative Assessment of BMP-Mediated Signaling Events. Nano Lett. 2015 Mar 11;15(3):1526-34

2014

• Horbelt, D, Boergermann, JH, Chaikuad, A, Alfano, I, Williams, E, Lukonin, I, Timmel, T, Bullock, AN and Knaus, P. (2015) Small Molecules Dorsomorphin and LDN-193189 Inhibit Myostatin/GDF8 Signaling and Promote Functional Myoblast Differentiation J. Biol. Chem. 6;290(6):3390-404
• Grünhagen J, Bhushan R, Degenkolbe E, Jäger M., Knaus P, Mundlos S, Robinson P and Ott CE (2014) MiR-497~195 cluster microRNAs regulate osteoblast differentiation by targeting BMP signaling. J Bone Miner Res. doi: 10.1002/jbmr2412
• Hiepen, C., Benn, A., Denkis, A., Lukonin, I., Weise, C., Boergermann, J., Knaus, P. (2014) BMP2-induced chemotaxis requires PI3K p55γ/p110α-dependent phosphatidylinositol (3,4,5)-triphosphate production and LL5β recruitment at the cytocortex. BMC Biol. 30;12:43.

2013

• Kopf, J, Paarmann, P, Hiepen, C, Horbelt, D, Knaus, P. (2013) BMP growth factor signaling in a biomechanical context. BioFactors, Oct 2013
• Bhushan R, Grünhagen J, Becker J, Robinson PN, Ott CE, Knaus P. miR-181a promotes osteoblastic differentiation through repression of TGF-β signaling molecules (2013) Int J Biochem Cell Biol. 45(3): 696-705 IF: 4,63
• Janke D, Jankowski J, Rüth M, Buschmann I, Lemke HD, Jacobi D, Knaus P, Spindler E, Zidek W, Lehmann K, Jankowski V. (2013) The "artificial artery" as in vitro perfusion model. PLoS One. 2013;8(3):e57227.
• Bagarova J, Vonner, AJ, Armstrong, KA, Börgermann, J, Lai, CSC, Deng, DY, Beppu H, Alfano I, Filippakopoulos P, Morrell NW, Bullock AN, Knaus P, Mishina Y and Yu PB (2013) Constitutively active ALK2 receptor mutants require type II receptor cooperation. Mol Cell Biol Jun;33(12): 2413-24.
  
  • Correction for Bagarova et al., “Constitutively Active ALK2 Receptor Mutants Require Type II Receptor Cooperation”. Mol Cell Biol. 2017 Sep 12;37(19). pii: e00284-17. doi: 10.1128/MCB.00284-17. Print 2017 Oct 1.
• Tykwinska K, Lauster R, Knaus P, Rosowski M. (2013) Growth and differentiation factor 3 induces expression of genes related to differentiation in a model of cancer stem cells and protects them from retinoic acid- induced apoptosis. PLoS One 8(8):e70612.
• Lichtner, B, Knaus, P, Lehrach, H, Adjaye J. (2013) BMP10 as a potent inducer of trophoblast differentiation in human embryonic and induced pluripotent stem cells. Biomaterials. 34(38):9789-802.

2012

• Pohl TL, Boergermann JH, Schwaerzer GK, Knaus P, Cavalcanti-Adam EA. (2012) Surface immobilization of bone morphogenetic protein 2 via a self-assembled monolayer formation induces cell differentiation. Acta Biomater. 2012 Feb;8(2):772-80. Epub 2011 Oct 20. PMID: 22040684 [PubMed - indexed for MEDLINE]
• Ruschke K, Hiepen C, Becker J, Knaus P. (2012) BMPs are mediators in tissue crosstalk of the regenerating musculoskeletal system. Cell and Tissue Research 347(3):521-44
• Kopf, J. Petersen, A, Duda, GN, and Knaus, P. (2012) BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway.BMC Biol., 30;10(1):37  
• Ehrlich, M., Gutman, O., Knaus, P., Henis, YI. (2012) Oligomeric interactions of TGF-ß and BMP receptors. FEBS Lett., 2012 Jul 4; 586(14) 1885-96
• Krauss-Etschmann S, Bush A, Bellusci S, Brusselle GG, Erik K Dahlén S, Dehmel S, Eickelberg O, Gibson G, Hylkema MN, Knaus P, Königshoff M, Lloyd CM, Macciarini P, Mailleux A, Marsland BJ, Postma DS, Roberts G, Samakovlis C, Stocks J, Vandesompele J, Wjst M, Holloway J. (2012) Of flies, mice and men: a systematic approach to understanding the early life origins of chronic lung disease. Thorax. 2012 Jul 10. [Epub ahead of print] PMID: 22781122
• Guzman, A, Zelman-Femiak, M, Boergermann, JH, Paschkowsky, S, Kreuzaler, PA, Fratzl, P, Harms GS, Knaus P. (2012) SMAD versus non-SMAD signalling is determined by lateral mobility of BMP receptors. J Biol Chem . 287(47):39492-504.
• Chaikuad A, Alfano I, Thangaratnarajah C, Horbelt D, Boergermann JH, Kettenbach A, Filippakopoulos P, Fedorov O, Gerber SA, Triffitt JT, von Delft F, Knapp S, Knaus P, Bullock AN. (2012) Molecular basis for cytosolic assembly and activation of BMP receptors. J Biol Chem 287(44): 36990-8
• Guo G, Muñoz-García B, Ott CE, Grünhagen J, Mousa SA, Pletschacher A, von Kodolitsch Y, Knaus P, Robinson PN. (2012) Antagonism of GxxPG fragments ameliorates manifestations of aortic disease in Marfan syndrome mice. Hum Mol Genet. 22(3):433-43.

2011

• Krause C, Guzman A, Knaus P. (2011) Noggin. Int J Biochem Cell Biol. 43(4):478-81
• Ott CE, Grünhagen J, Jäger M, Horbelt D, Schwill S, Kallenbach K, Guo G, Manke T, Knaus P, Mundlos S, Robinson PN (2011) MicroRNAs Differentially Expressed in Postnatal Aortic Development Downregulate Elastin via 3' UTR and Coding-Sequence Binding Sites. PLoS One.  Jan 31;6(1):e16250.      
• Marom B, Heining E, Knaus P, Henis YI. (2011) Formation of Stable Homomeric and Transient Heteromeric Bone Morphogenetic Protein (BMP) Receptor Complexes Regulates Smad Protein Signaling. J Biol Chem 286(22):19287-96.
• Ehrlich M, Horbelt D, Marom B, Knaus P, Henis YI. (2011) Homomeric and heteromeric complexes among TGF-β and BMP receptors and their roles in signaling. Cell Signal. 23(9):1424-32.
• Poorgholi Belverdi, M, Krause, C, Guzman, A, Knaus, P. Comprehensive analysis of TGF-β and BMP receptor interactomes. Eur J Cell Biol, 2011 Jun 27.
• Lange, C. Li, C., Manjubala, I., Wagermaier, W, Kühnisch, J., Kolanczyk, M, Mundlos, S., Knaus, P., Fratzl, P. (2011) Fetal and postnatal mouse bone tissue contains more calcium than is present in hydroxyapatite. J Struct Biol, 176(2):159-67.
• Schwaerzer GK, Hiepen C, Schrewe, H., Nickel J, Ploeger F, Sebald W, Müller T, Knaus P. (2011) New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): Mutation within the GDF5 knuckle epitope causes noggin-resistance. J Bone Miner Res. 27(2):429-42
• Heining, E, Bhushan, R, Paarmann, P, Henis, YI, Knaus. P. (2011)Spatial segregation of BMP/Smad signaling affects osteoblast differentiation in C2C12 cells. PLoS ONE, 6(10): e25163.
• Horbelt, D., Denkis, A., Knaus, P. (2011) A portrait of the TGF-ß/BMP family: Background matters. Int J Biochem Cell Biol. 2012 Mar; 44(3):469-74

2010

• Wagner DO, Sieber C, Bhushan R, Börgermann JH, Graf D, Knaus P. (2010) BMPs: from bone to body morphogenetic proteins. Sci Signal. Feb 2; 3(107)
• Glaeser JD, Geissler S, Ode A, Schipp CJ, Matziolis G, Taylor WR, Knaus P, Perka C, Duda G, Kasper G (2010) Modulation of MMP-2 levels by mechanical loading of three-dimensional mesenchymal stem cell constructs: impact on in vitro tube formation. Tissue Eng Part A. 2010 Oct;16(10):3139-48.
• Zelman-Femiak, M., Wang, K., Gromova, KV, Knaus, P., Harms, GS (2010) Covalent quantum dot receptor linkage via the acyl carrier protein for single-molecule tracking, internalization and trafficking studies. Biotechniques. 2010 Aug;49(2):574-9.
• Boergermann JH, Kopf J, Yu PB, Knaus P. (2010) Dorsomorphin and LDN-193189 inhibit BMP mediated Smad, p38 and Akt signalling in C2C12 cells. Int J Biochem Cell Biol. 42(11): 1802-7.
• Horbelt D, Guo G, Robinson PN, Knaus P. (2010) Quantitative analysis of TGFBR2 mutations in marfan syndrome related disorders reveals correlation between phenotypic severity and smad signaling activity. J. Cell Sciences 123: 4340-50

2009

• Bengtsson, L, Schwappacher, R. Roth, M., Hassel, S., and Knaus, P (2009) PP2A regulates BMP signalling by interacting with BMP receptor complexes and by dephosphorylating both the C-terminus and the linker region of Smad1. J. Cell Sci, 122(Pt 8):1248-57
• Sammar, M., Sieber, C., and Knaus, P. (2009) Biochemical and functional analyses of Ror2, Biochem Biophys Res Commun, 381(1):1-6.
• Schwappacher, R, Weiske, J, Heining, E, Ezerski, V, Marom, B, Henis, YI, Huber, O, and Knaus, P. (2009) Novel crosstalk to BMP signaling: cGMP-dependent kinase I modulates BMP receptor and Smad activity. EMBO J. 28(11):1537-50.
• Hauburger, A., von Einem, S., Schwaerzer, G., Buttstedt, A., Zebisch, M., Schräml, M., Hortschansky, P., Knaus, P., and Schwarz, E. (2009) The pro-form of BMP-2 interferes with BMP-2 signaling by competing with BMP-2 for IA receptor binding. FEBS J. 276(21):6386-98
• Sieber, C., Kopf, J., Hiepen, C. and Knaus, P. (2009) Recent Advances in BMP Receptor Signaling.Cytokine and Growth Factor Rev 20(5-6): 343-55.

2008

• Zavala-Gongora R, Derrer B, Gelmedin V, Knaus P, Brehm K. (2008) Molecular characterisation of a second structurally unusual AR-Smad without an MH1 domain and a Smad4 orthologue from Echinococcus multilocularis. Int J Parasitol. 38(2):161-76

2007

• Parker WL, Finnson KW, Soe-Lin H, Knaus P, Philip A. (2007) Expression and function of TbetaRII-B, a variant of the type II TGF-beta receptor, in human chondrocytes. Osteoarthritis Cartilage. 15(4):442-53.
• Morty RE, Nejman B, Kwapiszewska G, Hecker M, Zakrzewicz A, Kouri FM, Peters DM, Dumitrascu R, Seeger W, Knaus P, Schermuly RT, Eickelberg O. (2007) Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension. Arterioscler Thromb Vasc Biol. 27(5):1072-8   

2004 - 2006

• TGF-ß-resistant B cells from Chronic Lymphocytic Leukemia patients contain recurrent mutations in the signal sequence of the Type I TGF-ß Receptor. Cancer Detect Prev. 28(1):57-64.
• Schiemann, W., Rotzer, D., Pfeifer, W., Levi, E., Wang, Z., Petrogiannis-Haliotis, T., Rai, K., Knaus, P. and Kadin, M. (2004)
• Lutz, M., Krieglstein, K., Schmitt, S., ten Dijke, P., Sebald , W., Wizenmann A. and Knaus, P. (2004). NGF Mediates Activation of the Smad Pathway in PC12 Cells. Eur J Biochem. 271(5):920-31.
• Hassel, S., Eichner, A., Yakymovych, M., Hellman, U., Knaus, P., Souchelnytskyi, S. (2004) Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry. Proteomics 4(5):1346-58.
• Nohe, A., Keating,  E., Knaus, P and Petersen, NO (2004).
• Signal Transduction of Bone Morphogenetic Protein Receptors. Cell Signal. 16(3):291-9.

• Sammar, M., Stricker, S., Schwabe, G., Sieber, C., Hartung, A., Hanke, M., Oishi, I., Pohl, J., Minami, Y., Sebald, W., Mundlos, S., and Knaus, P.  (2004) Modulation of GDF5/BRI-b signaling through interaction with the tyrosine kinase receptor Ror2. Genes Cells 9(12):1227-38.
• Nohe A, Keating E, Underhill TM, Knaus P, Petersen NO. (2005)
• Dynamics and interaction of caveolin-1 isoforms with BMP-receptors. J Cell Sci. 118(Pt 3):643-50.
• Seemann, P., Schwappacher, R., Kjaer, KW, Krakow, D., Lehmann, K., Dawson, K., Stricker, S., Pohl, J., Plöger, F., Staub, E., Nickel, J., Knaus, P., Mundlos, S. (2005). Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2 .J Clin Invest. 115(9):2373-2381.
• Hassel, S., Yakymovych, M., Hellman, U., Rönnstrand, L., Knaus, P., Souchelnytskyi, S. (2006). Interaction and functional synergy between the serine/threonine kinase bone morphogenetic protein type II receptor with the tyrosine kinase stem cell factor receptor.J Cell Physiol.;206(2):457-467
• Meyer-ter-Vehn, T., Gebhardt, S., Sebald, W., Grehn, F., Schlunck, G., Knaus, P. (2006) P38-inhibitors prevent TGFβ-induced myofibroblast transdifferentiation in human tenon fibroblasts. Invest Ophthalmol Vis Sci 47(4):1500-9.
• Zavala-Góngora ,R., Kroner , A., Knaus ,P., Brehm, K. (2006) A member of the transforming growth factor-b receptor family from Echinococcus multilocularis functionally interacts with human bone morphogenetic protein 2. Mol Biochem Parasitol. 146(2):265-71.
• Klein, J., Ju, W., Heyer, J., Wittek, B., Haneke, T., Knaus, P., Kucherlapati, R., Bottinger, E.P., Nitschke, L., and Kneitz, B. (2006)
• B cell specific deficiency for Smad2 in vivo leads to defects in TGF-ß directed IgA switching and changes in B-cell fate. J Immunol. 176(4):2389-96.
• Sieber, C., Plöger, F., Schwappacher, R., Bechthold, R., Hanke, M., Kawai, S., Katsuura, M., Kimura, M., Mouler Rechtman, M., Henis, Y., Pohl, J., Knaus, P. (2006)
• Monomeric and dimeric GDF-5 show same type I receptor binding and oligomerization capability and same biological activity. Biol. Chem. 387(4):451-60.
• Hartung, A., Bitton-Worms, K., Mouler Rechtman, M., Wenzel, V., Börgermann, J., Hassel, S., Henis, Y., Knaus, P. (2006) Different routes of BMP receptor endocytosis influence BMP signaling. Mol Cell Biol. 26(20): 7791-805.
• Lehmann, K., Seemann, P., Boergermann, J., Morin, G., Reif, S., Knaus, P. and Mundlos S. (2006)
• A novel R486Q mutation in BMPR1B resulting in either a brachydactyly typeC/symphalangism-like phenotype or brachydactyly type A2. Eur. J. Hum Genet 14(12): 1248-54
• Hartung, A., Sieber, C., and Knaus, P. (2006) Yin and Yang in BMP signaling: impact on the pathology of diseases and potential for tissue regeneration. Signal Transduction 6, 314-328

2000 - 2003

• Gilboa, L., Nohe, A., Geissendörfer, T., Sebald, W., Henis Y. and Knaus, P. (2000). Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors. Mol. Biol. Cell. 11(3): 1023-35.
• Rotzer, D., Roth, M., Lutz, M., Lindemann, D., Sebald, W. and Knaus, P. (2001). Type III TGF-ß Receptor independent signaling of TGF-ß2 via TßRII-B, an alternative spliced TGF-ß Type II Receptor.  EMBO J. 20(3): 480-490
• Lindemann, D., Pietschmann, T. , Knaus, P. , Zentgraf, H.  and Rethwilm A. (2001). A particle-associated glycoprotein signal peptide essential for virus maturation and infectivity. J. Virol. 75 (13): 5762-71.
• Knaus, P. and Sebald, W. (2001).Cooperativity of binding epitopes and receptor chains in the BMP/TGFß superfamily. Biol. Chem. 282: 1189-1195.

• Koelbl, O., Knaus, P., Pohl, F., Flentje, M., Sebald, W. (2001). Radiation induced reduction of BMP-induced proteoglycansynthesis in a embryonal, mesenchymal tissue equivalent using the chicken „limb bud“test. Strahlenther Onkol. (8), 432-436.
• Nohe, A., Haßel, S., Ehrlich, M., Neubauer, F., Sebald, W., Henis, Y. and Knaus, P. (2002). The mode of BMP receptor oligomerization determines different BMP-2 signaling pathways. J Biol Chem. 277(7):5330-8.

• Feldmann, K., Sebald, W., and Knaus P. (2002). Resistance to TGF-ß1 mediated growth inhibition correlates with sustained Smad2 phosphorylation in primary murine splenocytes. Eur. J. Immunol. 32(5):1393-402.
• Lutz, M. and Knaus, P. (2002) Integration of the TGF-ß pathway into the cellular signalling network. Cellular Signalling. Cell Signal, 14 (12): 977-988.
• Pohl F, Hassel S, Nohe A, Flentje M, Knaus P, Sebald W, Koelbl O (2003). Radiation induced suppression of the BMP-2 (bone morphogenetic protein) signal transduction pathway in the pluripotent, mesenchymal cell line C2C12: an “in vitro” model for prevention of heterotopic ossification by radiotherapy. Radiat. Res. 159(3): 345-50.
• Hassel, S., Schmitt, S.,  Hartung, A., Roth, M.,  Nohe, A.,  Petersen, N., Ehrlich, M., Henis, Y., Sebald, W., and Knaus, P. (2003) Initiation of Smad-dependent and Smad-independent Signaling via Distinct BMP-receptor complexes. J Bone Joint Surg Am. 85-A Suppl 3:44-51.

• Lehmann, K., Seemann, P., Stricker, S., Sammar, M., Meyer,B., Süring, K., Majewski, F., Tinschert, S., Müller, D., Knaus, P., Nürnberg, P &  Mundlos, S. (2003). Mutations in BMPR1B cause Brachydactyly type A2.  Proc Natl Acad Sci U S A. Oct 14;100(21):12277-82
• Gekle M, Knaus P, Nielsen R, Mildenberger S, Freudinger R, Wohlfarth V, Sauvant C, Christensen EI. (2003) TGF-ß1 reduces megalin/cubilin-mediated endocytosis of albumin in proximal tubule derived OK-cells. J Physiol. Oct 15;552(Pt 2):471-81.
• Zavala-Góngora,R, KronerA., Wittek, B. KnausP, BrehmB. (2003). Molecular characterisation of structurally conserved and divergent Smad – factors from the fox-tapeworm Echinococcus multilocularis. Int. J. Parasitology 33(14):1665-77.
• Nohe, A., Keating, E., Underhill, MT, Knaus, P. and Petersen NO (2003). Effect of Distribution and Clustering of BMP receptors on the activation of signaling pathways. J Cell Sci.116(Pt 16):3277-84.

1986 - 1999

• Knaus, P., Betz, H., and Rehm, H. (1986). Expression of Synaptophysin during postnatal development of the mouse brain. J. of Neurochem., 47, 1302 - 1304.
• Schmitt, B., Knaus, P., Becker, C.-M., and Betz, H. (1987). The Mr 93000 polypeptide of the postsynaptic glycine receptor complex is a peripheral membrane protein. Biochemistry, 26, 805-811.
• Leube, R. E., Kaiser, P., Seiter, A., Zimbelmann, R., Franke, W. W., Rehm, H., Knaus, P., Prior, P., Betz, H., Reinke, H., Beyreuther, K., and Wiedenmann, B. (1987). Synaptophysin: molecular organization and mRNA expression as determined from cloned cDNA. EMBO J. 6, 3261-3268.
• Betz H, Becker CM, Grenningloh G, Hoch W, Knaus P, Langosch D, Malosio ML, Schmitt B, Thomas L. (1989). Homology and analogy in transmembrane channel design: lessons from synaptic membrane proteins. J Protein Chem. 8(3):325.
• Knaus, P. and Betz, H. (1990). Mapping of a dominant immunogenic region of synaptophysin, a major membrane protein of synaptic vesicles. FEBS Lett. 261, 358-360.
• Knaus, P., Marqueze-Pouey, B., Scherer, H., and Betz, H. (1990). Synaptoporin, a Novel Putative Channel Protein of Synaptic Vesicles. Neuron, 5, 453-462.
• Ovtscharoff, W., Bergmann, M., Marqueze-Pouey, B., Knaus, P., Betz, H., Grabs, D., Reisert, I., and Gratzl, M. (1993). Ontogeny of Synaptophysin and Synaptoporin in the central nervous system: differential expression in striatal neurons and their afferents during development. Developmental Brain Research 72, 219-225.
• Lin, H.Y., Moustakas, A., Knaus, P., Wells, R., Henis, Y. I., and Lodish, H. (1995). The soluble exoplasmic domain of the Type II Transforming Growth Factor (TGF)-ß Receptor. J. Biol. Chem. 270, 2747-2754.
• Knaus, P., Lindemann, D., DeCoteau, J.F., Perlman, R., Yankelev, H., Hille, M., Kadin, M.E. & Lodish, H.F. (1996). A dominant inhibitory mutant of the type II TGF-ß receptor in the malignant progression of a  cutaneous T-cell lymphoma. Mol. Cell. Biol. 16, 3480-3489.
• DeCoteau, J.F., Knaus, P.I., Yankelev, H., Reis, M., Lowsky, R., Lodish, H., Kadin, M. (1997). Loss of functional cell surface transforming growth factor-ß (TGF-ß) type I receptor correlates with insensitivity to TGF-ß in chronic lymphocytic leukemia. Proc. Natl. Acad. Sci. USA 94, 5877-5881.