Banner AG Freund 3

Structures solved in the AG Freund

1GYF: GYF domain of human CD2BP2

1GYF: GYF domain of human CD2BP2

Image from the RCSB PDB (www.rcsb.org) of PDB ID 1GYF (Freund, C., Doetsch, V., Nishizawa, K., Reinherz, E.L., Wagner, G.) (1999) The GYF domain is a novel structural fold that is involved in lymphoid signaling through proline-rich sequences. Nat.Struct.Biol. 6: 656-660

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1L2Z: GYF domain of CD2BP2 in complex with proline-rich peptide

1L2Z: GYF domain of CD2BP2 in complex with proline-rich peptide

Image from the RCSB PDB (www.rcsb.org) of PDB ID 1L2Z (Freund, C., Kuhne, R., Yang, H., Park, S., Reinherz, E.L., Wagner, G.) (2002) Dynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector molecules Embo J. 21: 5985-5995

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1RI9: hSH3C domain of the T cell protein ADAP

1RI9: hSH3C domain of the T cell protein ADAP

Image from the RCSB PDB (www.rcsb.org) of PDB ID 1RI9 (Heuer, K., Kofler, M., Langdon, G., Thiemke, K., Freund, C.) (2004) Structure of a Helically Extended SH3 Domain of the T Cell Adapter Protein ADAP. STRUCTURE 12: 603-610

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2GTJ: hSH3N domain of ADAP in its reduced form

2GTJ: hSH3N domain of ADAP in its reduced form

Image from the RCSB PDB (www.rcsb.org) of PDB ID 2GTJ (Zimmermann, J., Kuhne, R., Sylvester, M., Freund, C.) (2007) Redox-Regulated Conformational Changes in an SH3 Domain Biochemistry 46: 6971-6977

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2GTO: hSH3N domain of ADAP in its oxidized form

2GTO: hSH3N domain of ADAP in its oxidized form

Image from the RCSB PDB (www.rcsb.org) of PDB ID 2GTO (Zimmermann, J., Kuhne, R., Sylvester, M., Freund, C.) (2007) Redox-Regulated Conformational Changes in an SH3 Domain Biochemistry 46: 6971-6977

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3FMA: Smy2 GYF domain in complex with proline-rich peptide

3FMA: Smy2 GYF domain in complex with proline-rich peptide

Image from the RCSB PDB (www.rcsb.org) of PDB ID 3FMA (Ash, M.R., Faelber, K., Kosslick, D., Albert, G., Roske, Y., Kofler, M., Schuemann, M., Krause, E., Freund, C.) (2009) SMY2-type GYF domain recognition in mRNA surveillance complexes to be pubished

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3K3V: Smy2 GYF domain (S. cerevisiae)

3K3V: Smy2 GYF domain (S. cerevisiae)

Image from the RCSB PDB (www.rcsb.org) of PDB ID 3K3V (Ash, M.R., Faelber, K., Kosslick, D., Albert, G., Roske, Y., Freund, C.) (2010) SMY2-type GYF domain recognition in mRNA surveillance complexes to be published

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3PDO: HLA-DR1 with CLIP (102-120)

3PDO: HLA-DR1 with CLIP (102-120)

Image from the RCSB PDB (www.rcsb.org) of PDB ID 3PDO (Gunther, S., Schlundt, A., Sticht, J., Roske, Y., Heinemann, U., Wiesmuller, K.H., Jung, G., Falk, K., Rotzschke, O., Freund, C.) (2010) Bidirectional binding of invariant chain peptides to an MHC class II molecule. Proc.Natl.Acad.Sci.USA 107: 22219-22224

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3PGC: HLA-DR1 with CLIP (106-120) in its flipped orientation

3PGC: HLA-DR1 with CLIP (106-120) in its flipped orientation

Image from the RCSB PDB (www.rcsb.org) of PDB ID 3PGC (Gunther, S., Schlundt, A., Sticht, J., Roske, Y., Heinemann, U., Wiesmuller, K.H., Jung, G., Falk, K., Rotzschke, O., Freund, C.) (2010) Bidirectional binding of invariant chain peptides to an MHC class II molecule. Proc.Natl.Acad.Sci.USA 107: 22219-22224

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3PGD: HLA-DR1 with CLIP (106-120) in its canonical orientation

3PGD: HLA-DR1 with CLIP (106-120) in its canonical orientation

Image from the RCSB PDB (www.rcsb.org) of PDB ID 3PGD (Gunther, S., Schlundt, A., Sticht, J., Roske, Y., Heinemann, U., Wiesmuller, K.H., Jung, G., Falk, K., Rotzschke, O., Freund, C.) (2010) Bidirectional binding of invariant chain peptides to an MHC class II molecule. Proc.Natl.Acad.Sci.USA 107: 22219-22224

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4AEN: HLA-DR1 with covalently linked CLIP (106-120) in its flipped orientation

4AEN: HLA-DR1 with covalently linked CLIP (106-120) in its flipped orientation

Image from the RCSB PDB (www.rcsb.org) of PDB ID 4AEN (Schlundt, A., Gunther, S., Sticht, J., Wieczorek, M., Roske, Y., Heinemann, U., Freund, C.) (2012) Peptide Linkage to the Alpha-Subunit of Mhcii Creates a Stably Inverted Antigen Presentation Complex. J.Mol.Biol. 423: 294

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4AH2: HLA-DR1 with covalently linked CLIP (106-120) in its canonical orientation

4AH2: HLA-DR1 with covalently linked CLIP (106-120) in its canonical orientation

Image from the RCSB PDB (www.rcsb.org) of PDB ID 4AH2 (Schlundt, A., Gunther, S., Sticht, J., Wieczorek, M., Roske, Y., Heinemann, U., Freund, C.) (2012) Peptide Linkage to the Alpha-Subunit of Mhcii Creates a Stably Inverted Antigen Presentation Complex. J.Mol.Biol. 423: 294

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4X5X: HLA-DR1 mutant bN82A with covalently linked CLIP (106-120, M107W)

4X5X: HLA-DR1 mutant bN82A with covalently linked CLIP (106-120, M107W)

Image from the RCSB PDB (www.rcsb.org) of PDB ID 4X5X (Wieczorek, M., Sticht, J., Stolzenberg, S., Gunther, S., Wehmeyer, C., El Habre, Z., Alvaro-Benito, M., Noe, F., Freund, C.) (2016) MHC class II complexes sample intermediate states along the peptide exchange pathway. Nature Communications 7: 13224-13224

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