The vesicular ATPase: a missing link between acidification and exocytosis.

Wang, D. and Hiesinger, P.R.— 2013

The vesicular adenosine triphosphatase (ATPase) acidifies intracellular compartments, including synaptic vesicles and secretory granules. A controversy about a second function of this ATPase in exocytosis has been fuelled by questions about multiple putative roles of acidification in the exocytic process. Now, Poëa-Guyon et al. (2013. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201303104) present new evidence that the vesicular ATPase performs separate acidification and exocytosis roles and propose a mechanism for how these two functions are causally linked.

TitleThe vesicular ATPase: a missing link between acidification and exocytosis.
AuthorWang, D. and Hiesinger, P.R.
PublisherRockefeller University Press
Date20131028
Identifierdoi: 10.1083/jcb.201309130
Source(s)
Appeared InJ. Cell Biol. 203(2): 171-3
Languageeng
TypeText
Rights© 2013 Wang and Hiesinger. Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).