Beyond Molecular Codes: Simple Rules to Wire Complex Brain

Hassan, B.A. and Hiesinger, P.R.— 2015

Molecular codes, like postal zip codes, are generally considered a robust way to ensure the specificity of neuronal target selection. However, a code capable of unambiguously generating complex neural circuits is difficult to conceive. Here, we re-examine the notion of molecular codes in the light of developmental algorithms. We explore how molecules and mechanisms that have been considered part of a code may alternatively implement simple pattern formation rules sufficient to ensure wiring specificity in neural circuits. This analysis delineates a pattern-based framework for circuit construction that may contribute to our understanding of brain wiring.

TitleBeyond Molecular Codes: Simple Rules to Wire Complex Brain
AuthorHassan, B.A. and Hiesinger, P.R.
PublisherCell Press
Identifierdoi: 10.1016/j.cell.2015.09.031
Appeared InCell, 163(2):285-291
Rights© 2015 Elsevier Inc.