Systematic discovery of Rab GTPases with synaptic functions in Drosophila.

Chan, C.C., Scoggin, S., Wang, D., Cherry, S., Dembo, T., Greenberg, B., Jin, E.J., Kuey, C., Lopez, A., Mehta, S.Q., Perkins, T.J., Brankatschk, M., Rothenfluh, A., Buszczak, M.*, and Hiesinger, P.R.*— 2011

Neurons require highly specialized intracellular membrane trafficking, especially at synapses. Rab GTPases are considered master regulators of membrane trafficking in all cells, and only very few Rabs have known neuron-specific functions. Here, we present the first systematic characterization of neuronal expression, subcellular localization, and function of Rab GTPases in an organism with a brain.

TitleSystematic discovery of Rab GTPases with synaptic functions in Drosophila.
AuthorChan, C.C., Scoggin, S., Wang, D., Cherry, S., Dembo, T., Greenberg, B., Jin, E.J., Kuey, C., Lopez, A., Mehta, S.Q., Perkins, T.J., Brankatschk, M., Rothenfluh, A., Buszczak, M.*, and Hiesinger, P.R.*
PublisherCell Press
Date20111013
Identifierdoi: 10.1016/j.cub.2011.08.058
Source(s)
Relation
Appeared InCurr. Biol. 21(20): 1704-15
Languageeng
TypeText
Rights© 2011 Elsevier Ltd.