• Lardong JA, Driller JH, Depner H, Weise C, Petzoldt A, Wahl MC, Sigrist SJ, Loll B (2015):
    Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP
    Acta Crystallogr F Struct Biol Commun. 1;71(Pt 1):34-40
    View abstract at Pubmed


  • Petzoldt AG, Sigrist SJ (2014):
    Current Biology 24(22):R1076-80
    View abstract at Pubmed

  • Petzoldt AG, Lee YH, Khorramshahi O, Reynolds E, Plested AJ, Herzel H, Sigrist SJ (2014):
    Gating characteristics control glutamate receptor distribution and trafficking in vivo
    Current Biology 24(17):2059-65
    View abstract at Pubmed

  • Depner H, Lützkendorf J, Babkir HA, Sigrist SJ, Holt MG (2014):
    Differential centrifugation-based biochemical fractionation of the Drosophila adult CNS
    Nature Protocols 9(12):2796-808
    View abstract at Pubmed

  • Andlauer TF, Scholz-Kornehl S, Tian R, Kirchner M, Babikir HA, Depner H, Loll B, Quentin C, Gupta VK, Holt MG, Dipt S, Cressy M, Wahl MC, Fiala A, Selbach M, Schwärzel M, Sigrist SJ (2014):
    Drep-2 is a novel synaptic protein important for learning and memory
    eLife 2014;3:e03895
    View abstract at Pubmed
  • Li L, Tian X, Zhu M, Bulgari D, Böhme MA, Goettfert F, Wichmann C, Sigrist SJ, Levitan ES, Wu C (2014):
    Drosophila Syd-1, Liprin-a, and Protein Phosphatase 2A B' Subunit Wrd Function in a Linear Pathway to Prevent Ectopic Accumulation of Synaptic Materials in Distal Axons.
    J Neuroscience 34(25):8474-87
    View abstract at Pubmed
  • Eisenberg T, Schroeder S, Andryushkova A, Pendl T, Küttner V, Bhukel A, Mariño G, Pietrocola F, Harger A, Zimmermann A, Moustafa T, Sprenger A, Jany E, Büttner S, Carmona-Gutierrez D, Ruckenstuhl C, Ring J, Reichelt W, Schimmel K, Leeb T, Moser C, Schatz S, Kamolz LP, Magnes C, Sinner F, Sedej S, Fröhlich KU, Juhasz G, Pieber TR, Dengjel J, Sigrist SJ, Kroemer G, Madeo F. (2014):
    Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan.
    Cell metabolism 19(3):431-44
    View abstract at Pubmed
  • Jasmin Podufall, Rui Tian, Elena Knoche, Dmytro Puchkov, Alexander M. Walter, Stefanie Rosa, Christine Quentin, Anela Vukoja, Nadja Jung, Andre Lampe, Carolin Wichmann, Mathias Böhme, Harald Depner, Yong Q. Zhang, Jan Schmoranzer, Stephan J. Sigrist, Volker Haucke (2014):
    A Presynaptic Role for the Cytomatrix Protein GITin Synaptic Vesicle Recycling.
    Cell Reports 7(5):1417-25
    View abstract at Pubmed
  • Walter AM, Haucke V, Sigrist SJ (2014):
    Neurotransmission: spontaneous and evoked release filing for divorce.
    Current Biology 24(5):R192-4
    View abstract at Pubmed
  • Sigrist SJ, Carmona-Gutierrez D, Gupta VK, Bhukel A, Mertel S, Eisenberg T, Madeo F (2014):
    Spermidine-triggered autophagy ameliorates memory during aging.
    Autophagy 10(1):178-9
    View abstract at Pubmed


  • Gupta VK, Scheunemann L, Eisenberg T, Mertel S, Bhukel A, Koemans TS, Kramer JM, Liu KS, Schroeder S, Stunnenberg HG, Sinner F, Magnes C, Pieber TR, Dipt S, Fiala A, Schenck A, Schwaerzel M, Madeo F, Sigrist SJ (2013):
    Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner.
    Nature Neuroscience 16(10):1453–1460
    View abstract at Pubmed
  • Matkovic T, Siebert M, Knoche E, Depner H, Mertel S, Owald D, Schmidt M, Thomas U, Sickman A, Kamin D, Hell SW, Bürger J, Hollmann C, Mielke T, Wichmann C, Sigrist SJ (2013):
    The Bruchpilot cytomatrix determines the size of the readily releasable pool of synaptic vesicles.
    J Cell Biol 202(4):667-83
    View abstract at Pubmed
  • Maglione M, Sigrist SJ (2013):
    Seeing the forest tree by tree: super-resolution light microscopy meets the neurosciences.
    Nature Neuroscience 16(7):790-7
    View abstract at Pubmed
  • Gupta VK, Sigrist SJ (2013):
    Sperm(idine) answers the next generation.
    Cell Cycle 12(4):542-3
    View abstract at Pubmed


  • Müller M, Liu KSY, Sigrist SJ, Davis GW (2012):
    RIM Controls Homeostatic Plasticity through Modulation of the Readily-Releasable Vesicle Pool.
    J Neuroscience, 32(47):16574-85
    View abstract at Pubmed
  • Owald D, Khorramshahi O, Gupta VK, Banovic D, Depner H, Fouquet W, Wichmann C, Mertel S, Eimer S, Reynolds E, Holt M, Aberle H, Sigrist SJ (2012):
    Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic assembly.
    Nature Neuroscience, 15(9):1219-26
    View abstract at Pubmed
  • Sigrist SJ, Sabatini BL (2012):
    Optical super-resolution microscopy in neurobiology.
    Curr Opin Neurobiol. 22(1):86-93
    View abstract at Pubmed
  • Abbasi-Moheb L, Mertel S, Gonsior M, Nouri-Vahid L, Kahrizi K, Cirak S, Wieczorek D, Motazacker MM, Esmaeeli-Nieh S, Cremer K, Weißmann R, Tzschach A, Garshasbi M, Abedini SS, Najmabadi H, Ropers HH, Sigrist SJ, Kuss AW (2012):
    Mutations in NSUN2 Cause Autosomal-Recessive Intellectual Disability.
    Am J Hum Genet., 90(5):847-55
    View abstract at Pubmed
  • Jordan-Alvarez S, Fouquet W, Sigrist SJ, Acebes A (2012):
    Presynaptic PI3K activity triggers the formation of glutamate receptors at neuromuscular terminals of Drosophila.
    J Cell Sci., 125(15):3621-9
    View abstract at Pubmed
  • Lampe A, Haucke V, Sigrist SJ, Heilemann M, Schmoranzer J (2012):
    Multi-colour direct STORM with red emitting carbocyanines.
    Biol Cell. 104(4):229-37
    View abstract at Pubmed
  • Thomas U, Sigrist SJ (2012):
    Glutamate Receptors in Synaptic Assembly and Plasticity: Case Studies on Fly NMJs.
    Adv Exp Med Biol. 970(1):3-28.
    View abstract at Pubmed


  • Liu KSY, Siebert M, Mertel M, Knoche E, Wegener S, Wichmann C, Matkovic T, Muhammad K, Depner H, Mettke C, B&u ;ckers J, Hell SW, Müller M, Davis GW, Schmitz D, Sigrist SJ (2011):
    RIM-Binding Protein, a Central Part of the Active Zone, Is Essential for Neurotransmitter Release.
    Science 334(6062):1565-9
    View abstract at Pubmed
  • Wichmann C, Sigrist SJ (2011):
    Dem Innenleben der Synapsen auf der Spur.
    Neuroforum 11(4):144-51
    Download as pdf
  • Miskiewicz K, Jose LE, Bento-Abreu A, Fislage M, Taes I, Kasprowicz J, Swerts J, Sigrist SJ, Versees W, Robberecht W, Verstreken P (2011):
    ELP3 controls active zone morphology by acetylating the ELKS family member Bruchpilot.
    Neuron 72(5):776-88
    View abstract at Pubmed
  • Waites CL, Leal-Ortiz SA, Andlauer TFM, Sigrist SJ, Garner CC (2011):
    Piccolo regulates the dynamic assembly of presynaptic f-actin.
    J Neurosci. 31(40):14250-63
    View abstract at Pubmed
  • Christiansen F, Zube C, Andlauer TFM, Wichmann C, Fouquet W, Owald D, Mertel S, Leiss F, Tavosanis G, Farca Luna AJ, Fiala A, Sigrist SJ (2011):
    Presynapses in Kenyon Cell Dendrites in the Mushroom Body Calyx of Drosophila.
    J Neurosci. 31(26):9696-9707
    View abstract at Pubmed
  • Haucke V, Neher E, Sigrist SJ (2011):
    Protein scaffolds in the coupling of synaptic exocytosis and endocytosis.
    Nat Rev Neurosci. 12(3):127-138
    View abstract at Pubmed
  • Sigrist SJ, Andlauer TFM (2011):
    Fighting the famine with an amine: synaptic strategies for smart search.
    Nature Neuroscience 14(2):124-6
    View abstract at Pubmed
  • Sigrist SJ, Schmitz D (2011):
    Structural and functional plasticity of the cytoplasmic active zone.
    Curr Opin Neurobiol. 21(1):144-50
    View abstract at Pubmed


  • Hallermann S, Kittel RJ, Wichmann C, Weyhersmüller A, Fouquet W, Mertel S, Owald D, Eimer S, Depner H, Schwärzel M, Sigrist SJ, Heckmann M (2010):
    Naked Dense Bodies Provoke Depression.
    J Neuroscience 30(43):14340-14345
    View abstract
  • Kremer MC, Christiansen F, Leiss F, Paehler M, Knapek S, Andlauer TFM, Förstner F, Kloppenburg P, Sigrist SJ, Tavosanis G (2010):
    Structural Long-Term Changes at Mushroom Body Input Synapses.
    Current Biology 20(21):1938-44
    View abstract at Pubmed
  • Geis C, Weishaupt A, Hallermann S, Grünewald B, Wessig C, Wultsch T, Reif A, Byts N, Beck M, Jablonka S, Boettger MK, Uçeyler N, Fouquet W, Gerlach M, Meinck HM, Sirén AL, Sigrist SJ, Toyka KV, Heckmann M, Sommer C (2010):
    Stiff person syndrome-associated autoantibodies to amphiphysin mediate reduced GABAergic inhibition.
    Brain 133(11):3166-80
    View abstract at Pubmed
  • Wichmann C, Sigrist SJ (2010):
    The Active Zone T-Bar - A Plasticity Module?
    J Neurogenetics 24(3):133-145
    View abstract at Pubmed
  • Banovic D, Khorramshahi O, Owald D, Wichmann C, Riedt T, Fouquet W, Tian R, Sigrist SJ, Aberle H (2010):
    Drosophila Neuroligin 1 Promotes Growth and Postsynaptic Differentiation at Glutamatergic Neuromuscular Junctions.
    Neuron 66(5):724-738
    View abstract at Pubmed
  • Andlauer TFM, Sigrist SJ (2010):
    In Vivo Imaging of Drosophila Larval Neuromuscular Junctions to Study Synapse Assembly.
    Cold Spring Harbor Laboratory Press - Drosophila Neurobiology Methods: A Laboratory Manual; Chapter 21
    View abstract at CSHL Press
  • Bachmann A, Kobler O, Kittel RJ, Wichmann C, Sierralta J, Sigrist SJ, Gundelfinger ED, Knust E, Thomas U (2010):
    A perisynaptic ménage à trois between Dlg, DLin-7, and Metro controls proper organization of Drosophila synaptic junctions.
    J. Neurosci. 30(17):5811-24
    View abstract at Pubmed
  • Owald D, Fouquet W, Schmidt M, Wichmann C, Mertel S, Depner H, Christiansen F, Zube C, Quentin C, Körner J, Urlaub U, Mechtler K, Sigrist SJ (2010):
    A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila.
    J. Cell Biol. 188(4):565-579
    View abstract at Pubmed


  • Engerer P, Sigrist SJ (2009):
    Relax? Don't do it! - Linking presynaptic vesicle clustering with mechanical tension.
    HFSP J.;3(6):367-72
    View abstract at Pubmed
  • Sigrist SJ, Plested AJ (2009):
    How to button a bouton with alpha(2)deltas.
    Nature Neuroscience 12(11):1357-8
    View abstract at Pubmed
  • Andlauer TFM, Sigrist SJ (2009):
    Intravitale Bildgebung in Drosophila-Larven.
    Biospektrum 6/2009:632-635
    Download the pdf-file  or visit the  BIOspektrum-Homepage
  • Fouquet W, Owald D, Wichmann C, Mertel S, Depner H, Dyba M, Hallermann S, Kittel RJ, Eimer S, Sigrist SJ (2009):
    Maturation of active zone assembly by Drosophila Bruchpilot.
    J. Cell Biol. 186(1):129-145
    View abstract at Pubmed
    Evaluated at the Faculty of 1000
  • Leiss F, Koper E, Hein I, Fouquet W, Lindner J, Sigrist SJ, Tavosanis G (2009):
    Characterization of dendritic spines in the Drosophila central nervous system.
    Dev Neurobiol. 69(4):221-34
    View abstract at Pubmed
  • Sigrist SJ (2009):
    The Yin and Yang of synaptic active zone assembly.
    Sci Signal. 2(70):pe32
    View abstract at Pubmed
  • Owald D, Sigrist SJ (2009):
    Assembling the presynaptic active zone.
    Curr Opin Neurobiol. 19(3):311-8
    View abstract at Pubmed
  • Raghu SV, Joesch M, Sigrist SJ, Borst A, Reiff DF (2009):
    Synaptic organization of lobula plate tangential cells in Drosophila: Dalpha7 cholinergic receptors.
    J Neurogenet. 23(1-2):200-9
    View abstract at Pubmed


  • Schmid A, Sigrist SJ (2008):
    Analysis of neuromuscular junctions: histology and in vivo imaging.
    Methods Mol Biol. 420:239-251
    View abstract at Pubmed
  • Schmid A, Hallermann S, Kittel RJ, Khorramshahi O, Frölich AM, Quentin C, Rasse TM, Mertel S, Heckmann M, Sigrist SJ (2008):
    Activity-dependent site-specific changes of glutamate receptor composition in vivo.
    Nature Neuroscience 11(6):659-666
    View abstract at Pubmed
  • Ataman B, Ashley J, Gorczyca M, Ramachandran P, Fouquet W, Sigrist SJ, Budnik V (2008):
    Rapid Activity-Dependent Modifications in Synaptic Structure and Function Require Bidirectional Wnt Signaling.
    Neuron 57(5):705-18
    View abstract at Pubmed


  • Füger P, Behrends LB, Mertel S, Sigrist SJ, Rasse TM (2007):
    Live imaging of synapse development and measuring protein dynamics using two-color fluorescence recovery after photo-bleaching at Drosophila synapses.
    Nature Protocols 2(12):3285-98
    View abstract at Pubmed
  • Besse F, Mertel S, Kittel RJ, Wichmann C, Rasse TM, Sigrist SJ and Ephrussi A (2007):
    The Ig cell adhesion molecule Basigin controls compartmentalization and vesicle release at Drosophila melanogaster synapses. 
    J. Cell Biology 177(5):843-55
    View abstract at Pubmed


  • Schmid A, Qin G, Wichmann C, Kittel RJ, Mertel S, Fouquet W, Schmidt M, Heckmann M, Sigrist SJ (2006):
    Non-NMDA-type glutamate receptors are essential for maturation but not for initial assembly of synapses at Drosophila neuromuscular junctions. 
    J. Neuroscience 26(44):11267-77
    View abstract at Pubmed
  • Swan LE, Schmidt M, Schwarz T, Ponimaskin E, Prange U, Boeckers T, Thomas U, Sigrist SJ (2006):
    Complex interaction of Drosophila GRIP PDZ domains and Echinoid during muscle morphogenesis. 
    EMBO J. 25(15):3640-51
    View abstract at Pubmed
  • Ataman B, Ashley J, Gorczyca D, Gorczyca M, Mathew D, Wichmann C, Sigrist SJ, Budnik V (2006):
    Nuclear trafficking of Drosophila Frizzled-2 during synapse development requires the PDZ protein dGRIP. 
    PNAS 103(20):7841-6
    View abstract at Pubmed
  • Kittel RJ, Wichmann C, Rasse TM, Fouquet W, Schmidt M, Schmid A, Wagh DA, Pawlu C, Kellner RR, Willig KI, Hell SW, Buchner E, Heckmann M, Sigrist SJ (2006):
    Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release. 
    Science 312(5776):1051-4
    View abstract at Pubmed
  • Wagh DA, Rasse TM, Asan E, Hofbauer A, Schwenkert I, Dürrbeck H, Buchner S, Dabauvalle MC, Schmidt M, Qin G, Wichmann C, Kittel R, Sigrist SJ, Buchner E (2006):
    Bruchpilot, a protein with homology to ELKS/CAST, is required for structural integrity and function of synaptic active zones in Drosophila. 
    Neuron 49(6):833-44
    View abstract at Pubmed


  • Rasse TM, Fouquet W, Schmid A, Kittel RJ, Mertel S, Sigrist CB, Schmidt M, Guzman A, Merino C, Qin G, Quentin C, Madeo F, Heckmann M, Sigrist SJ (2005):
    Glutamate receptor dynamics organizing synapse formation in vivo. 
    Nature Neuroscience 8(7):898-905
    View abstract at Pubmed
  • Qin G, Schwarz T, Kittel RJ, Schmid A, Rasse TM, Kappei D, Ponimaskin E, Heckmann M, Sigrist SJ (2005):
    Four different subunits are essential for expressing the synaptic glutamate receptor at neuromuscular junctions of Drosophila. 
    J. Neuroscience 25(12):3209-18
    View abstract at Pubmed


  • Swan LE, Wichmann C, Prange U, Schmid A, Schmidt M, Schwarz T, Ponimaskin E, Madeo F, Vorbrüggen G, Sigrist SJ (2004):
    A glutamate receptor-interacting protein homolog organizes muscle guidance in Drosophila. 
    Genes Dev. 18(2):223-37
    View abstract at Pubmed

2003 and older

  • Sigrist SJ, Reiff DF, Thiel PR, Steinert JR, Schuster CM (2003):
    Experience-dependent strengthening of Drosophila neuromuscular junctions. 
    J. Neuroscience 23(16):6546-56
    View abstract at Pubmed
  • Sigrist SJ, Thiel PR, Reiff DF, Lachance PE, Lasko P, Schuster CM (2000):
    Postsynaptic translation affects the efficacy and morphology of neuromuscular junctions. 
    Nature 405(6790):1062-5
    View abstract at Pubmed